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PKMYT1 serine/threonine kinase is a member of a family of neural specific, zinc finger-containing DNA-binding proteins which binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing nervous system. MYT1 of the oligodendrocyte lineage, along with a closely related CCHC zinc finger, is expressed in developing neurons in the mammalian central nervous system. The recombinant PKMYT1 fragments containing either the upstream 2 zinc fingers or the downstream 4 zinc fingers bound the same cis regulatory element in the PLP1 promoter in vitro and DNA binding required Zn2+, but not other divalent cations.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Myt1 kinase; protein phosphatase 1, regulatory subunit 126
基因别名: MYT1; PKMYT1; PPP1R126
UniProt ID: (Human) Q99640
Entrez Gene ID: (Human) 9088