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PKP2 Antibody (PA5-95165) in WB
Western blot analysis of PKP2 in Lane 1: rat cardiac muscle tissue lysate (40 µg), Lane 2: human placenta tissue lysate (40 µg), Lane 3: rat brain tissue lysate (40 µg), Lane 4: rat intestine tissue lysate (40 µg), Lane 5: HeLa whole cell lysate (40 µg), Lane 6: Jurkat whole cell lysate (40 µg), Lane 7: 293T whole cell lysate (40 µg), Lane 8: MCF-7 whole cell lysate (40 µg), Lane 9: U87 whole cell lysate (40 µg). Samples were incubated with PKP2 polyclonal antibody (Product # PA5-95165).
产品信息
PA5-95165
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human Plakophilin 2 (863-881aa KKTDFVNSRTAKAYHSLKD).
偶联物
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2806970
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: Rat Cardiac Muscle Tissue, Human Placenta Tissue, Rat Brain Tissue, Rat Intestine Tissue, HELA whole cell, JURKAT whole cell, 293T whole cell, MCF-7 whole cell, U87 whole cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
Plakophilins 1, 2, 3 and 4 (PKP1-4) influence development and participate in linking cadherins to cytoskeletal intermediate filaments. Plakophilins 1-4 contain arm-repeat (armadillo) domains and localize to nuclei and cell desmosomes (cell-cell junctions found in suprabasal layers of stratifying epithelia that undergo mechanical stress). Plakophilin 1 mediates increases in desmosomal protein content, desmosome assembly and regulation of cell migration. Plakophilin 2 is important for desmosome assembly and is an essential morphogenic factor and architectural component of the heart. Plakophilin 4 is a component of desmosomal adhesion plaques that regulates junctional plaque organization and cadherin function.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Plakophilin-2
基因别名: 1200008D14Rik; 1200012P04Rik; AA516617; ARVD9; PKP2; Pkp2l
UniProt ID: (Human) Q99959, (Mouse) Q9CQ73, (Rat) F1M7L9
Entrez Gene ID: (Human) 5318, (Mouse) 67451, (Rat) 287925
molecular_function
protein kinase C binding
protein binding
sodium channel regulator activity
intermediate filament binding
protein complex scaffold
ion channel binding
alpha-catenin binding
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
cadherin binding involved in cell-cell adhesion
intermediate filament binding protein
desmosome assembly
heart development
negative regulation of cell proliferation
positive regulation of sodium ion transport
gap junction assembly
single organismal cell-cell adhesion
negative regulation of cell migration
adherens junction maintenance
intermediate filament bundle assembly
maintenance of organ identity
ventricular cardiac muscle tissue morphogenesis
lipid homeostasis
cardiac muscle cell action potential
cardiac muscle cell action potential involved in contraction
ventricular cardiac muscle cell action potential
cell-cell signaling involved in cardiac conduction
cell communication by electrical coupling involved in cardiac conduction
bundle of His cell-Purkinje myocyte adhesion involved in cell communication
regulation of heart rate by cardiac conduction
establishment of protein localization to plasma membrane
regulation of ventricular cardiac muscle cell action potential
regulation of bicellular tight junction assembly
bundle of His cell to Purkinje myocyte communication
