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PLA2R1 Antibody (PA5-119863) in IHC (P)
Immunohistochemistry (Paraffin) analysis of paraffin-embedded rat testis tissue using PLA2R1 Polyclonal Antibody (Product # PA5-119863). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the PLA2R1 antibody at a dilution of 1:40... View More
产品信息
PA5-119863
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human PLA2R amino acids 1021-1100.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
TBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2913435
产品详细信息
Positive Control: Mouse skeletal muscle tissue lysate, Raji cell lysate, rat testis tissue, SiHa.^M
^M
Subcellular Location: Cell membrane, Secreted.
靶标信息
Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phosholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 180 kDa secretory phospholipase A2 receptor; C-type lectin domain family 13 member C; M-type receptor; mannose receptor, C type 2; phospholipase A2 receptor 1, 180kD; phospholipase A2 receptor 1, 180kDa; phospholipase A2, group IB, pancreas, receptor; PLA2-I receptor; PLA2-R; Secretory phospholipase A2 receptor
基因别名: CLEC13C; Mrc2; PLA2-R; Pla2g1br; PLA2G1R; PLA2IR; PLA2R; PLA2R1
UniProt ID: (Human) Q13018, (Mouse) Q62028
Entrez Gene ID: (Human) 22925, (Rat) 295631, (Mouse) 18779
cytokine production
receptor-mediated endocytosis
positive regulation of DNA damage response, signal transduction by p53 class mediator
reactive oxygen species metabolic process
positive regulation of arachidonic acid secretion
replicative senescence
oxidative stress-induced premature senescence
negative regulation of phospholipase A2 activity
negative regulation of arachidonic acid secretion
endocytosis
