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产品信息
PA5-20827
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
An 18 amino acid peptide from near the carboxy terminus of human CKIP1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11154792
产品详细信息
A suggested positive control is human lung tissue lysate.
PA5-20827 can be used with blocking peptide PEP-0941.
靶标信息
CKIP1 was identified through a yeast-two hybrid screening as a protein that would interact with only one of the two catalytic subunits of the casein kinase 2 complex. CKIP1 is a pleckstrin homology domain-containing protein localized within the nucleus and at the plasma membrane that interacts with CK2alpha but not CK2alpha', and is thought to play a role in targeting CK2alpha to a particular cellular location. CKIP1 has been implicated in muscle differentiation and the regulation of cell morphology and actin cytoskeleton. CKIP1 can also interact with other proteins such as ATM, an upstream kinase of p53, and recruit the nuclear ATM to the plasma membrane, suggesting CKIP1 may regulate ATM function through re-localizing ATM. CKIP1 can also form a complex with the kinase AKT, leading to a down-regulation of PI3K/AKT signaling and suppression of tumor growth in vivo.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-Jun-binding protein; Casein kinase 2-interacting protein 1; CK2 interacting protein 1; CK2 interacting protein 1; HQ0024c protein; CK2-interacting protein 1; HQ0024c protein; JBP; Jun zipper-associated 2; Osteoclast maturation-associated gene 120 protein; PH domain-containing family O member 1; pleckstrin homology domain containing, family O member 1; Pleckstrin homology domain-containing family O member 1; RP11-458I7.3; TNF intracellular domain-interacting protein
基因别名: 2810052M02Rik; CKIP-1; CKIP1; HQ0024c; JBP; JZA-20; Jza2; OC120; PLEKHO1; RGD1311487
UniProt ID: (Human) Q53GL0, (Mouse) Q9JIY0, (Rat) Q5BJM5
Entrez Gene ID: (Human) 51177, (Mouse) 67220, (Rat) 310674
