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PLK3 Antibody (PA5-97143) in WB
Western blot analysis of PLK3 in extracts of various cell lines. Samples were incubated with PLK3 Polyclonal antibody (Product # PA5-97143) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
产品信息
PA5-97143
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 487-646 of human PLK3 (NP_0040642)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808945
产品详细信息
Immunogen sequence: VLFNDGTHMA LSANRKTVHY NPTSTKHFSF SVGAVPRALQ PQLGILRYFA SYMEQHLMKG GDLPSVEEVE VPAPPLLLQW VKTDQALLML FSDGTVQVNF YGDHTKLILS GWEPLLVTFV ARNRSACTYL ASHLRQLGCS PDLRQRLRYA LRLLRDRSPA; Positive Samples: A-549, HT-1080, SKOV3, 293T, U2OS, Mouse liver, Rat liver; Cellular Location: Cytoplasm, Golgi apparatus, Nucleus, centrosome, cytoskeleton, microtubule organizing center, nucleolus
靶标信息
PLK3 is a member of the polo family of serine/threonine kinases. PLK3 is involved in the regulation of M phase in the cell cycle. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: cytokine inducible kinase; Cytokine-inducible serine/threonine-protein kinase; FGF-inducible kinase; PLK-3; Polo-like kinase 3; Proliferation-related kinase; serine-threonine kinase; Serine/threonine-protein kinase PLK3
基因别名: CNK; FNK; PLK-3; PLK3; PRK
UniProt ID: (Human) Q9H4B4, (Rat) Q9R011
Entrez Gene ID: (Human) 1263, (Rat) 58936, (Mouse) 12795
G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
negative regulation of transcription from RNA polymerase II promoter
response to reactive oxygen species
protein phosphorylation
apoptotic process
response to osmotic stress
cellular response to DNA damage stimulus
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
mitotic cell cycle checkpoint
endomitotic cell cycle
response to radiation
cytoplasmic microtubule organization
regulation of cytokinesis
negative regulation of apoptotic process
protein kinase B signaling
mitotic G1/S transition checkpoint
regulation of cell division
Golgi disassembly
positive regulation of intracellular protein transport
regulation of signal transduction by p53 class mediator
positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
regulation of synaptic plasticity
regulation of long-term neuronal synaptic plasticity
cell cycle
phosphorylation
