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PLP1 Antibody (MA1-80034) in ICC/IF
Immunofluorescence analysis of PLP1 was performed using Hep G2 and MCF7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with PLP1 Monoclonal Antibody (plpc1) (Product # MA1-80034) at 1:100 dilution in 0.1% BSA and incubated overnight at 4 degree and then labeled with Goat anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32723, 1:2000 dilution... View More
产品信息
MA1-80034
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Dog,
Human,
Mouse,
Non-human primate,
Rat
已发表种属
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
plpc1
抗原
Synthetic peptide GRGTKF corresponding to C terminal region of myelin proteolipid protein
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
<0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2299793
产品详细信息
Predicted to react with all mammals based on sequence homology.
Mouse anti myelin proteolipid protein antibody, clone plpc1 recognizes myelin proteolipid protein (PLP) in many mammalian species (Stoffel et al. 1985).
靶标信息
PLP1 is a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.This gene encodes a transmembrane proteolipid protein that is the predominant myelin protein present in the central nervous system. It may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause X-linked Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively spliced transcript variants encoding distinct isoforms or having different 5' UTRs, have been identified for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Lipophilin; major myelin proteolipid protein; Myelin proteolipid protein; myelin synthesis deficiency; PLP; proteolipid; proteolipid protein (myelin) 1; Proteolipid protein (Pelizaeus-Merzbacher disease spastic paraplegia 2 uncomplicated); Proteolipid protein (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); proteolipid protein 1 (Pelizaeus-Merzbacher disease, spastic paraplegia 2, uncomplicated); rump shaker
基因别名: DM20; GPM6C; HLD1; jimpy; jp; MMPL; msd; PLP; PLP/DM20; PLP1; PMD; rsh; SPG2
UniProt ID: (Bovine) P04116, (Dog) P23294, (Human) P60201, (Mouse) P60202, (Rat) P60203
Entrez Gene ID: (Bovine) 281410, (Dog) 481002, (Human) 5354, (Mouse) 18823, (Rat) 24943
inflammatory response
axon ensheathment
positive regulation of gene expression
astrocyte development
central nervous system myelination
myelination
long-chain fatty acid biosynthetic process
cell maturation
axon development
integrin-mediated signaling pathway
chemical synaptic transmission
substantia nigra development
glial cell differentiation
