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PLXNB2 Antibody (PA5-47880) in WB
Western blot analysis from lysates of M1 mouse myeloid leukemia cell line, mouse lung tissue, and mouse ovary tissue. PVDF membrane was probed with 0.5 µg/mL of Sheep Anti-mouse Plexin B2 Antigen Affinity-purified Polyclonal Antibody (Product # PA5-47880) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody. Specific bands were detected for Plexin B2 at approximately 240 and 150 kDa (as indicated). This experiment was conducted under reducing conditions.
产品信息
PA5-47880
产品规格
种属反应
Mouse
已发表种属
Mouse,
Zebrafish
宿主/亚型
Sheep
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CHO-derived recombinant mouse Plexin B2 Leu20-Trp1029
偶联物
Unconjugated
形式
Lyophilized
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5% trehalose
内含物
No Preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2610560
产品详细信息
In direct ELISAs, approximately 9% cross-reactivity with recombinant human Plexin B2 is observed, and less than 1% cross-reactivity with recombinant mouse Plexin B3 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.
靶标信息
Plexin-B2 is a member of the Semaphorin receptor family. The semaphorin family consists of membrane and secreted proteins involved in attraction and repulsion of neuronal guidance cues. Plexin-B1 is a transmembrane protein that can be cleaved converting the single chain precursor into a heterodimeric receptor. It has been shown to bind Sema4D/CD100 and is involved in axon development in mouse embryos. Sema4D also plays a role in the immune system interacting with CD72. Plexin-B2's possible role in the immune system has not been characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: differentially expressed in brain tumors; MM1KIAA0315dJ402G11.3; Plexin-B2
基因别名: Debt; plexin-B2; Plxnb2
UniProt ID: (Mouse) B2RXS4
Entrez Gene ID: (Mouse) 140570
neural tube closure
regulation of protein phosphorylation
signal transduction
multicellular organism development
neuroblast proliferation
brain development
regulation of cell shape
regulation of GTPase activity
positive regulation of axonogenesis
semaphorin-plexin signaling pathway
regulation of neuron migration
