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Invitrogen
PNP Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
产品信息
PA5-51616
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human PNP. Recombinant protein control fragment (Product #RP-98841).
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2645720
产品详细信息
Immunogen sequence: YTYEDYKNTA EWLLSHTKHR PQVAIICGSG LGGLTDKLTQ AQIFDYGEIP NFPRSTVPGH AGRLVFGFLN GRACVMMQGR FHMYEGYPLW KVTFPVRVFH LLGVDTLVVT NAAGGLNPKF EVGDIMLIRD HINLPGFSGQ NPLRGPNDER GAPHR
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 87%.
靶标信息
This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epididymis secretory sperm binding protein Li 156an; HEL-S-156an; Inosine phosphorylase; inosine phosphorylase {ECO:0000250|UniProtKB:P00491}; Inosine-guanosine phosphorylase; nucleoside phosphorylase; PNP; PNP {ECO:0000250|UniProtKB:P00491}; Purine nucleoside phosphorylase; purine nucleoside phosphorylase {ECO:0000250|UniProtKB:P00491}; purine-nucleoside phosphorylase 1; purine-nucleoside:orthophosphate ribosyltransferase
基因别名: AL024301; AU015798; NP; Np-1; Np-2; PNP; Pnp1; PRO1837; PUNP
UniProt ID: (Human) P00491, (Mouse) P23492
Entrez Gene ID: (Human) 4860, (Mouse) 18950, (Rat) 290029
nucleoside binding
purine nucleobase binding
purine-nucleoside phosphorylase activity
drug binding
phosphate ion binding
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
kinase
nucleotide kinase
transferase
metabolite interconversion enzyme
nucleobase-containing compound metabolic process
inosine catabolic process
purine nucleotide catabolic process
nicotinamide riboside catabolic process
immune response
NAD biosynthesis via nicotinamide riboside salvage pathway
urate biosynthetic process
positive regulation of T cell proliferation
response to drug
purine-containing compound salvage
positive regulation of alpha-beta T cell differentiation
interleukin-2 secretion
positive regulation of T cell mediated cytotoxicity
deoxyinosine catabolic process
deoxyguanosine catabolic process
GTP biosynthetic process
intrinsic apoptotic signaling pathway in response to DNA damage
apoptotic mitochondrial changes
nucleoside metabolic process
response to gamma radiation
purine nucleoside metabolic process
positive regulation of B cell differentiation
positive regulation of DNA repair
dGTP metabolic process
guanosine catabolic process
negative regulation of T cell apoptotic process
