Invitrogen

PON1 Polyclonal Antibody

PON1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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PON1 Antibody (PA5-28997) in IHC (P)

PON1 Polyclonal Antibody detects PON1 protein at cytoplasm in mouse liver by immunohistochemical analysis. Sample: Paraffin-embedded mouse liver. PON1 Polyclonal Antibody (Product # PA5-28997) diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min.

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产品信息

PA5-28997

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

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其他PubMed (Misc)

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产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Full length human PON1 Recombinant protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

0.1M tris glycine, pH 7, with 20% glycerol

内含物

0.01% thimerosal

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2546473

产品详细信息

Recommended positive controls: human plasma, human liver, HepG2.

Predicted reactivity: Mouse (82%), Rat (81%), Pig (84%), Rabbit (85%), Bovine (82%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

The paraoxonase (PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson's disease.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Spp24 is associated with endocytic signalling, lipid metabolism, and discrimination of tissue integrity for 'leaky-gut' in inflammatory bowel disease.

Scientific reports

Wasinger VC,Lu K,Yau YY,Nash J,Lee J,Chang J,Paramsothy S,Kaakoush NO,Mitchell HM,Leong RWL

PA5-28997 was used in Reverse Binding Studies to assess to assess the role of SPP24 in mucosal healing.

Fri Jul 31 00:00:00 EDT 2020

Expression levels of paraoxonase-1 in aortic valve tissue are associated with the progression of calcific aortic valve stenosis.

Journal of thoracic disease

Song J,Zheng Q,Ma X,Zhang Q,Xu Z,Zou C,Wang Z

PA5-28997 was used in Immunohistochemistry to detect for the first time, the expression of paraoxonase-1 in human aortic valve tissue, and identify a relationship between paraoxonase-1 levels and the severity of aortic valve calcification.

Mon Jul 01 00:00:00 EDT 2019

Dysregulated Lipid Transport Proteins Correlate With Pathogenesis and Outcome in Severe Alcoholic Hepatitis.

Hepatology communications

Maras JS,Das S,Bhat A,Kumar Vyas A,Yadav G,Chaudhary S,Sukriti S,Gupta AC,Bihari C,Mahiwall R,Sarin SK

Published figure using PON1 polyclonal antibody (Product # PA5-28997) in Immunohistochemistry (Paraffin)

Sun Dec 01 00:00:00 EST 2019

生物信息学

蛋白别名: A esterase 1; A-esterase 1; Aromatic esterase 1; arylesterase 1; arylesterase B-type; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; ESAesterase A; esterase A; K-45; paraoxonase B-type; PON 1; serum aryldiakylphosphatase; Serum aryldialkylphosphatase 1; Serum paraoxonase/arylesterase 1

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基因别名: ESA; MVCD5; PON; PON1

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UniProt ID: (Human) P27169, (Mouse) P52430

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Entrez Gene ID: (Human) 5444, (Mouse) 18979

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功能

aryldialkylphosphatase activity arylesterase activity calcium ion binding phospholipid binding protein homodimerization activity acyl-L-homoserine-lactone lactonohydrolase activity high-density lipoprotein particle binding hydrolase activity metal ion binding

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