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PON1 Antibody (MA5-38069) in IHC (P)
Immunohistochemistry analysis of PON1 in paraffin-embedded human liver. Samples were incubated with PON1 Monoclonal antibody (Product # MA5-38069) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-38069
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC2001
抗原
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human PON1 (P27169)
偶联物
形式
Liquid
浓度
0.27 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897987
产品详细信息
Positive Samples: Mouse liver, HepG2
Immunogen sequence: TGSEDLEILP NGLAFISSGL KYPGIKSFNP NSPGKILLMD LNEEDPTVLE LGITGSKFDV SSFNPHGIST FTDEDNAMYL LVVNHPDAKS TVELFKFQEE E
靶标信息
The paraoxonase (PON) gene-family in humans has three members, PON1, PON2, and PON3, aligned next to each other on the long arm of chromosome 7q21.3-22.1. PON1 of these is synthesized primarily in the liver and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). And It hydrolyzes the active metabolites of several other organophosphorus insecticides (e.g., chlorpyrifos oxon, diazoxon), as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and considered to be an independent risk factor for Parkinson's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A esterase 1; A-esterase 1; Aromatic esterase 1; arylesterase 1; arylesterase B-type; EC 3.1.1.2; EC 3.1.1.81; EC 3.1.8.1; ESAesterase A; esterase A; K-45; paraoxonase B-type; PON 1; serum aryldiakylphosphatase; Serum aryldialkylphosphatase 1; Serum paraoxonase/arylesterase 1
基因别名: ESA; MVCD5; PON; PON1
UniProt ID: (Human) P27169, (Mouse) P52430, (Rat) P55159
Entrez Gene ID: (Human) 5444, (Mouse) 18979, (Rat) 84024
blood circulation
cholesterol metabolic process
response to toxic substance
positive regulation of cholesterol efflux
dephosphorylation
aromatic compound catabolic process
positive regulation of transporter activity
carboxylic acid catabolic process
organophosphate catabolic process
phosphatidylcholine metabolic process
positive regulation of binding
response to fluoride
lipid metabolic process
response to nutrient levels
negative regulation of plasma lipoprotein particle oxidation
response to fatty acid
response to external stimulus
