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PPAR Delta Polyclonal Antibody

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说明书
实验方案
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说明书
实验方案
技术支持

产品信息

600-401-420

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500- 1:2,000
-

免疫组化 (IHC)

1:500
-

酶联免疫吸附实验 (ELISA)

1:30,000-1:70,000
-

免疫沉淀 (IP)

1:500-1:5,000
-
产品规格

种属反应

Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Anti-PPAR delta antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the amino terminus of mouse PPAR delta.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

内含物

0.01% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

产品详细信息

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Directed against mouse PPAR delta protein. A BLAST analysis was used to suggest reactivity with this protein from mouse and rat sources based on 100% homology for the immunogen sequence. Cross-reactivity with PPAR delta protein from human, chimpanzee and rabbit may occur as this sequence shows 85% homology with the protein from these sources. Cross-reactivity with PPAR delta homologues from other sources has not been determined. No reactivity is expected against other subtypes of PPAR.

靶标信息

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: MGC3931; NUC1; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor delta; peroxisome proliferator activator receptor beta; peroxisome proliferator activator receptor, delta; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; PPARdelta/beta

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基因别名: Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta; PPAR[b]; Pparb; Pparb/d; Ppard; PPARdelta

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UniProt ID: (Mouse) P35396

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Entrez Gene ID: (Rat) 25682, (Mouse) 19015

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功能
DNA binding transcription factor activity, sequence-specific DNA binding steroid hormone receptor activity transcription coactivator activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding fatty acid binding drug binding zinc ion binding lipid binding sequence-specific DNA binding protein heterodimerization activity NF-kappaB binding linoleic acid binding enzyme activator activity prostacyclin receptor activity metal ion binding retinoid X receptor binding C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator
参与通路
negative regulation of transcription from RNA polymerase II promoter placenta development proteoglycan metabolic process lipid metabolic process fatty acid beta-oxidation vitamin A metabolic process heart development embryo implantation cell proliferation positive regulation of cell proliferation axon ensheathment phospholipid biosynthetic process mRNA transcription response to glucose response to organic substance positive regulation of phosphatidylinositol 3-kinase signaling response to activity negative regulation of smooth muscle cell migration fatty acid transport fatty acid oxidation cell differentiation negative regulation of cell growth intracellular receptor signaling pathway cell-substrate adhesion positive regulation of insulin secretion negative regulation of collagen biosynthetic process response to vitamin A wound healing regulation of cell proliferation negative regulation of apoptotic process steroid hormone mediated signaling pathway keratinocyte proliferation regulation of fat cell differentiation positive regulation of epidermis development positive regulation of transcription, DNA-templated positive regulation of vasodilation decidualization negative regulation of smooth muscle cell proliferation negative regulation of epithelial cell proliferation negative regulation of inflammatory response keratinocyte migration adipose tissue development cellular response to hypoxia apoptotic signaling pathway transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter apoptotic process G-protein coupled receptor signaling pathway epidermis development cellular process anagen positive regulation of catalytic activity regulation of insulin secretion cellular response to lipopolysaccharide
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