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PPAR delta Antibody (MA5-27427) in ICC/IF
Immunofluorescence analysis of PPARB/D was performed using FADU cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with PPARB/D Mouse Monoclonal Antibody (Product # MA5-27427) at 1:100 dilution in 0.1% BSA and incubated overnight at 4 degree and then labeled ... View More
产品信息
MA5-27427
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI4D10
抗原
Human recombinant protein fragment corresponding to amino acids 1-244 of PPARD produced in E.coli
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2725077
靶标信息
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MGC3931; NUC1; NUCI; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta
基因别名: FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB; PPARD
UniProt ID: (Human) Q03181
Entrez Gene ID: (Human) 5467
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
drug binding
zinc ion binding
lipid binding
sequence-specific DNA binding
protein heterodimerization activity
NF-kappaB binding
linoleic acid binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
glucose metabolic process
proteoglycan metabolic process
generation of precursor metabolites and energy
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
lipid metabolic process
fatty acid beta-oxidation
vitamin A metabolic process
apoptotic process
heart development
embryo implantation
cholesterol metabolic process
cell proliferation
axon ensheathment
phospholipid biosynthetic process
fatty acid catabolic process
mRNA transcription
response to glucose
positive regulation of phosphatidylinositol 3-kinase signaling
response to activity
regulation of skeletal muscle satellite cell proliferation
negative regulation of smooth muscle cell migration
glucose transport
fatty acid transport
cell differentiation
negative regulation of cell growth
intracellular receptor signaling pathway
cell-substrate adhesion
positive regulation of insulin secretion
negative regulation of collagen biosynthetic process
response to vitamin A
wound healing
negative regulation of apoptotic process
steroid hormone mediated signaling pathway
positive regulation of skeletal muscle tissue regeneration
keratinocyte proliferation
positive regulation of fat cell differentiation
negative regulation of myoblast differentiation
positive regulation of epidermis development
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
decidualization
negative regulation of smooth muscle cell proliferation
negative regulation of epithelial cell proliferation
negative regulation of inflammatory response
keratinocyte migration
adipose tissue development
cellular response to lipopolysaccharide
cellular response to hypoxia
apoptotic signaling pathway
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of myoblast proliferation
