Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
5467-MSM6-P1ABX
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
PCRP-PPARD-4C2
抗原
Recombinant fragment (around 72-146) of human PPARD protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS
内含物
no preservative
保存条件
-20°C or -80°C if preferred
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
Positive Control:HeLa or MCF-7 cells.
Cellular Location: Nucleus.
靶标信息
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: MGC3931; NUC1; NUCI; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; OTTHUMP00000016256; OTTHUMP00000016257; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta
基因别名: FAAR; NR1C2; NUC1; NUCI; NUCII; PPARB; PPARD
UniProt ID: (Human) Q03181
Entrez Gene ID: (Human) 5467
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
drug binding
zinc ion binding
lipid binding
sequence-specific DNA binding
protein heterodimerization activity
NF-kappaB binding
linoleic acid binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
glucose metabolic process
proteoglycan metabolic process
generation of precursor metabolites and energy
regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
lipid metabolic process
fatty acid beta-oxidation
vitamin A metabolic process
apoptotic process
heart development
embryo implantation
cholesterol metabolic process
cell proliferation
axon ensheathment
phospholipid biosynthetic process
fatty acid catabolic process
mRNA transcription
response to glucose
positive regulation of phosphatidylinositol 3-kinase signaling
response to activity
regulation of skeletal muscle satellite cell proliferation
negative regulation of smooth muscle cell migration
glucose transport
fatty acid transport
cell differentiation
negative regulation of cell growth
intracellular receptor signaling pathway
cell-substrate adhesion
positive regulation of insulin secretion
negative regulation of collagen biosynthetic process
response to vitamin A
wound healing
negative regulation of apoptotic process
steroid hormone mediated signaling pathway
positive regulation of skeletal muscle tissue regeneration
keratinocyte proliferation
positive regulation of fat cell differentiation
negative regulation of myoblast differentiation
positive regulation of epidermis development
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of vasodilation
decidualization
negative regulation of smooth muscle cell proliferation
negative regulation of epithelial cell proliferation
negative regulation of inflammatory response
keratinocyte migration
adipose tissue development
cellular response to lipopolysaccharide
cellular response to hypoxia
apoptotic signaling pathway
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of myoblast proliferation
