Target of Interest
Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-144904
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 300-381.
偶联物
Unconjugated
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_3092037
产品详细信息
Immunogen sequence: PPHKANQDNP FRASPKLKSS CKTVVPPPSK KPRYSESSGT QGNNSTKKGP EQSELYAQLS KSSVLTGGHE ERKTKRPSLR LF
Antigen sequence identity: Mouse 87%; Rat 88%
靶标信息
PGC1 alpha is a transcriptional coactivator that regulates the genes involved in energy metabolism. It interacts with PPARgamma, which permits it's interaction with multiple transcription factors. PGC-1 Alpha can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. It may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: L-PGC-1alpha; Ligand effect modulator 6; ligand effect modulator-6; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5; peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; pgc-1 alpha; PGC-1-alpha; PPAR gamma coactivator variant form; PPARgamma coactivator 1alpha; PPARGC-1-alpha
基因别名: LEM6; PGC-1(alpha); PGC-1alpha; PGC-1v; PGC1; PGC1A; PPARGC1; PPARGC1A
UniProt ID: (Human) Q9UBK2
Entrez Gene ID: (Human) 10891
nucleotide binding
RNA polymerase II transcription cofactor activity
DNA binding
transcription coactivator activity
RNA binding
protein binding
transcription factor binding
ligand-dependent nuclear receptor binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
chromatin DNA binding
ubiquitin protein ligase binding
peroxisome proliferator activated receptor binding
alpha-tubulin binding
sequence-specific DNA binding
androgen receptor binding
promoter-specific chromatin binding
transcription cofactor
response to reactive oxygen species
mitophagy
temperature homeostasis
cellular glucose homeostasis
negative regulation of protein phosphorylation
response to dietary excess
response to ischemia
galactose metabolic process
gluconeogenesis
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
mRNA processing
protein complex assembly
mitochondrion organization
positive regulation of transcription from RNA polymerase II promoter by pheromones
aging
digestion
circadian rhythm
androgen metabolic process
RNA splicing
response to cold
positive regulation of mitochondrion organization
skeletal muscle atrophy
response to muscle activity
response to electrical stimulus involved in regulation of muscle adaptation
negative regulation of smooth muscle cell migration
fatty acid oxidation
cerebellum development
respiratory electron transport chain
androgen receptor signaling pathway
forebrain development
circadian regulation of gene expression
cellular response to oxidative stress
positive regulation of histone acetylation
cellular response to potassium ion
response to statin
response to drug
response to starvation
regulation of circadian rhythm
response to leucine
negative regulation of neuron apoptotic process
cellular respiration
positive regulation of gluconeogenesis
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
positive regulation of smooth muscle cell proliferation
negative regulation of smooth muscle cell proliferation
protein stabilization
brown fat cell differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
flavone metabolic process
adipose tissue development
cellular response to lipopolysaccharide
cellular response to nitrite
cellular response to caffeine
cellular response to fructose stimulus
cellular response to glucose stimulus
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to follicle-stimulating hormone stimulus
cellular response to estradiol stimulus
cellular response to hypoxia
cellular response to transforming growth factor beta stimulus
response to epinephrine
response to norepinephrine
negative regulation of mitochondrial fission
cellular response to thyroid hormone stimulus
negative regulation of neuron death
response to metformin
positive regulation of cellular respiration
positive regulation of mitochondrial DNA metabolic process
positive regulation of muscle tissue development
positive regulation of glomerular visceral epithelial cell apoptotic process
cellular response to ionomycin
cellular response to resveratrol
response to methionine
adaptive thermogenesis
positive regulation of progesterone biosynthetic process
negative regulation of receptor activity
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of energy homeostasis
positive regulation of ATP biosynthetic process
