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产品信息
PA5-37385
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length human PPBP
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2554040
产品详细信息
This antibody detects endogenous protein at a molecular weight of 14 kDa.
Purity is >95% by SDS-PAGE.
靶标信息
Members of the a-chemokine subfamily of inducible, secreted, pro-inflammatory cytokines contain a similar motif, in which the first two cysteine residues are separated by a single residue (Cys-X-Cys), and are also chemotactic for neutrophils. The platelet basic protein (PBP), a member of the a-chemokine family, resides in the a-granules of platelets and is released upon their activation. Proteolytic cleavage of the amino terminus of PBP leads to the generation of several peptides, which include mature PBP, connective tissue-activating peptide III (CTAP III, also designated low affinity platelet factor IV (LA-PF4)), b-thromboglobulin (b-TG), and neutrophil-activating peptide 2 (NAP-2). PBP and its N-truncated derivatives mediate inflammation and wound healing. Specifically, NAP-2 activates chemotaxis and degranulation in neutrophils during inflammation. The gene encoding human PBP maps to chromosome 4q12-q13.
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生物信息学
蛋白别名: beta-thromboglobulin; C-X-C motif chemokine 7; chemokine (C-X-C motif) ligand 7; connective tissue-activating peptide III; CXC chemokine ligand 7; LDGF; Leukocyte-derived growth factor; low-affinity platelet factor IV; Macrophage-derived growth factor; MDGF; neutrophil-activating peptide 2; neutrophil-activating peptide-2; PBP; Platelet basic protein; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); small inducible cytokine B7; small inducible cytokine subfamily B, member 7; Small-inducible cytokine B7; thrombocidin 1; thrombocidin 2; thromboglobulin, beta-1
基因别名: B-TG1; Beta-TG; CTAP-III; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; PBP; PPBP; SCYB7; TC1; TC2; TGB; TGB1; THBGB; THBGB1
UniProt ID: (Human) P02775
Entrez Gene ID: (Human) 5473
leukocyte migration involved in inflammatory response
platelet degranulation
positive regulation of leukocyte chemotaxis
inflammatory response
immune response
G-protein coupled receptor signaling pathway
glucose transport
neutrophil chemotaxis
response to lipopolysaccharide
regulation of cell proliferation
defense response to bacterium
neutrophil degranulation
positive regulation of cell division
chemokine-mediated signaling pathway
glucose transmembrane transport
