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PRDX2 Antibody (PA5-79862) in WB
Western blot analysis of PRDX2 in Lane 1: rat brain tissue lysate, Lane 2: rat kidney tissue lysate, Lane 3: HeLa cell lysate, Lane 4: JURKAT cell lysate, Lane 5: 293T cell lysate, Lane 6: A549 cell lysate. Sample was incubated with PRDX2 polyclonal antibody (Product # PA5-79862).
产品信息
PA5-79862
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human Peroxiredoxin 2 (181-198aa DTIKPNVDDSKEYFSKHN).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide, 0.05mg thimerosal
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746977
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Peroxiredoxin (Prx) is a growing peroxidase family, whose mammalian members have been known to connect with cell proliferation, differentiation, and apoptosis. Many isoforms (about 50 proteins), collected in accordance to the amino acid sequence homology, particularly amino-terminal region containing active site cysteine residue, and the thiol-specific antioxidant activity, distribute throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2-Cys, atypical 2-Cys Prx, and 1-Cys Prx. Except Prx VI belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20 - 30 kilodalton in molecular size and vary in subcellular localization: Prx I, II, and VI in cytosol, Prx III in mitochondria, Prx IV in ER and secretion, Prx V showing complicated distribution including peroxisome, mitochondria and cytosol.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Calpromotin; epididymis secretory sperm binding protein Li 2a; HGNC:9353; MGC4104; Natural killer cell-enhancing factor B; NKEF-B; Peroxiredoxin-2; protector protein; PRP; Prx II-1; thiol specific antioxidant protein; thiol-specific antioxidant 1; Thiol-specific antioxidant protein; thioredoxin dependent peroxide reductase 1; Thioredoxin peroxidase 1; thioredoxin reductase; Thioredoxin-dependent peroxide reductase 1; Thioredoxin-dependent peroxiredoxin 2; torin; Trx dependent peroxide reductase 1; TSA
基因别名: AL022839; Band-8; HEL-S-2a; NKEF-B; NKEFB; PRDX2; PRP; PRX2; PRXII; PTX1; TDPX1; TDX1; Torin; TPx; TPx-B; TPX1; TR; TSA
UniProt ID: (Human) P32119, (Mouse) Q61171, (Rat) P35704
Entrez Gene ID: (Human) 7001, (Mouse) 21672, (Rat) 29338
response to reactive oxygen species
response to oxidative stress
removal of superoxide radicals
cellular response to oxidative stress
hydrogen peroxide catabolic process
regulation of apoptotic process
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
cell redox homeostasis
oxidation-reduction process
activation of MAPK activity
respiratory burst involved in inflammatory response
regulation of hydrogen peroxide metabolic process
positive regulation of blood coagulation
negative regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
response to lipopolysaccharide
T cell proliferation
hydrogen peroxide metabolic process
negative regulation of T cell differentiation
thymus development
homeostasis of number of cells
negative regulation of reactive oxygen species metabolic process
negative regulation of extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
