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产品信息
H00051422-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3C4
抗原
PRKAG2 (AAH20540, 191 a.a. approximately 300 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: AFMKQNLDEL GIGTYHNIAF IHPDTPIIKA LNIFVERRIS ALPVVDESGK VVDIYSKFDV INLAAEKTYN NLDITVTQAL QHRSQYFEGV VKCNKLEILE TIVDRIVRAE
靶标信息
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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生物信息学
蛋白别名: 5'-AMP-activated protein kinase subunit gamma-2; ampk gamma; AMPK gamma2; AMPK subunit gamma-2; H91620p; OTTHUMP00000211956; protein kinase, AMP-activated, gamma 2 non-catalytic subunit
基因别名: AAKG; AAKG2; CMH6; H91620p; PRKAG2; WPWS
UniProt ID: (Human) Q9UGJ0
Entrez Gene ID: (Human) 51422
glycogen metabolic process
regulation of glycolytic process
protein phosphorylation
negative regulation of protein kinase activity
fatty acid biosynthetic process
ATP biosynthetic process
carnitine shuttle
cell cycle arrest
positive regulation of peptidyl-threonine phosphorylation
sterol biosynthetic process
macroautophagy
regulation of fatty acid metabolic process
activation of protein kinase activity
intracellular signal transduction
regulation of fatty acid biosynthetic process
positive regulation of protein kinase activity
regulation of fatty acid oxidation
regulation of glucose import
negative regulation of protein serine/threonine kinase activity
regulation of signal transduction by p53 class mediator
