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PRKCZ Antibody (H00005590-D01P) in WB
Western Blot analysis of PRKCZ expression in transfected 293T cell line (H00005590-T01) by PRKCZ MaxPab polyclonal antibody.
Lane 1: PRKCZ transfected lysate(67.70 KDa).
Lane 2: Non-transfected lysate.
Lane 1: PRKCZ transfected lysate(67.70 KDa).
Lane 2: Non-transfected lysate.
产品信息
H00005590-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PRKCZ (NP_002735.3, 1 a.a. approximately 592 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MPSRTGPKME GSGGRVRLKA HYGGDIFITS VDAATTFEEL CEEVRDMCRL HQQHPLTLKW VDSEGDPCTV SSQMELEEAF RLARQCRDEG LIIHVFPSTP EQPGLPCPGE DKSIYRRGAR RWRKLYRANG HLFQAKRFNR RAYCGQCSER IWGLARQGYR CINCKLLVHK RCHGLVPLTC RKHMDSVMPS QEPPVDDKNE DADLPSEETD GIAYISSSRK HDSIKDDSED LKPVIDGMDG IKISQGLGLQ DFDLIRVIGR GSYAKVLLVR LKKNDQIYAM KVVKKELVHD DEDIDWVQTE KHVFEQASSN PFLVGLHSCF QTTSRLFLVI EYVNGGDLMF HMQRQRKLPE EHARFYAAEI CIALNFLHER GIIYRDLKLD NVLLDADGHI KLTDYGMCKE GLGPGDTTST FCGTPNYIAP EILRGEEYGF SVDWWALGVL MFEMMAGRSP FDIITDNPDM NTEDYLFQVI LEKPIRIPRF LSVKASHVLK GFLNKDPKER LGCRPQTGFS DIKSHAFFRS IDWDLLEKKQ ALPPFQPQIT DDYGLDNFDT QFTSEPVQLT PDDEDAIKRI DQSEFEGFEY INPLLLSTEE SV
靶标信息
The PKC family of serine/threonine kinases, including PRKCZ (PKC zeta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC zeta plays a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function.
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生物信息学
蛋白别名: kinase nPKC-zeta; KPCZ; nPKC-zeta; nPKC-zeta PRKCZ; Protein kinase C zeta type; protein kinase C, zeta
基因别名: PKC-ZETA; PKC2; PRKCZ
UniProt ID: (Human) Q05513
Entrez Gene ID: (Human) 5590
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein binding
ATP binding
potassium channel regulator activity
protein kinase binding
protein domain specific binding
phospholipase binding
insulin receptor substrate binding
metal ion binding
14-3-3 protein binding
non-receptor serine/threonine protein kinase
microtubule cytoskeleton organization
positive regulation of cell-matrix adhesion
protein phosphorylation
inflammatory response
signal transduction
transforming growth factor beta receptor signaling pathway
long-term memory
positive regulation of cell proliferation
insulin receptor signaling pathway
cell migration
peptidyl-serine phosphorylation
establishment of cell polarity
negative regulation of protein complex assembly
actin cytoskeleton reorganization
activation of phospholipase D activity
activation of protein kinase B activity
positive regulation of interleukin-4 production
negative regulation of apoptotic process
positive regulation of T-helper 2 cell differentiation
positive regulation of glucose import
negative regulation of insulin receptor signaling pathway
positive regulation of insulin receptor signaling pathway
vesicle transport along microtubule
negative regulation of peptidyl-tyrosine phosphorylation
positive regulation of NF-kappaB transcription factor activity
protein heterooligomerization
negative regulation of hydrolase activity
membrane depolarization
membrane hyperpolarization
long-term synaptic potentiation
positive regulation of ERK1 and ERK2 cascade
protein kinase C signaling
protein localization to plasma membrane
neuron projection extension
positive regulation of excitatory postsynaptic potential
positive regulation of T-helper 2 cell cytokine production
positive regulation of interleukin-5 secretion
positive regulation of interleukin-13 secretion
positive regulation of interleukin-10 secretion
