Abnova

PRKCZ Monoclonal Antibody (2D1)

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抗体检测数据 (1)

PRKCZ Antibody in Western Blot (WB)

PRKCZ Antibody in Western Blot (WB)

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PRKCZ Antibody (H00005590-M01) in WB

Western Blot analysis of PRKCZ expression in transfected 293T cell line by PRKCZ monoclonal antibody (M01), clone 2D1. Lane 1: PRKCZ transfected lysate(67.7 KDa). Lane 2: Non-transfected lysate. .

PRKCZ Antibody in Western Blot (WB)

Product Image Gallery

PRKCZ Antibody in Western Blot (WB) — Western Blot analysis of PRKCZ expression in transfected 293T cell line by PRKCZ monoclonal antibody (M01), clone 2D1. Lane 1: PRKCZ transfected lysate(67.7 KDa). Lane 2: Non-transfected lysate. .

产品信息

H00005590-M01

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

功能检测 (Functional)

1-5 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

2D1

抗原

PRKCZ (AAH08058, 165 a.a. approximately 255 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product may be used with Western Blot (Transfected lysate).

Immunogen sequence: KLLVHKRCHG LVPLTCRKHM DSVMPSQEPP VDDKNEDADL PSEETDGIAY ISSSRKHDSI KDDSEDLKPV IDGMDGIKIS QGLGLQDFDL I

靶标信息

The PKC family of serine/threonine kinases, including PRKCZ (PKC zeta), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity. PKC alpha, beta I, beta II and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent. PKC zeta plays a key regulatory role in a variety of cellular functions including cell growth and differentiation, gene expression, hormone secretion and membrane function.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: kinase nPKC-zeta; KPCZ; nPKC-zeta; nPKC-zeta PRKCZ; Protein kinase C zeta type; protein kinase C, zeta

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基因别名: PKC-ZETA; PKC2; PRKCZ

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UniProt ID: (Human) Q05513

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Entrez Gene ID: (Human) 5590

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protein kinase activity protein serine/threonine kinase activity protein kinase C activity protein binding ATP binding potassium channel regulator activity protein kinase binding protein domain specific binding phospholipase binding insulin receptor substrate binding metal ion binding 14-3-3 protein binding non-receptor serine/threonine protein kinase

参与通路

microtubule cytoskeleton organization positive regulation of cell-matrix adhesion protein phosphorylation inflammatory response signal transduction transforming growth factor beta receptor signaling pathway long-term memory positive regulation of cell proliferation insulin receptor signaling pathway cell migration peptidyl-serine phosphorylation establishment of cell polarity negative regulation of protein complex assembly actin cytoskeleton reorganization activation of phospholipase D activity activation of protein kinase B activity positive regulation of interleukin-4 production negative regulation of apoptotic process positive regulation of T-helper 2 cell differentiation positive regulation of glucose import negative regulation of insulin receptor signaling pathway positive regulation of insulin receptor signaling pathway vesicle transport along microtubule negative regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity protein heterooligomerization negative regulation of hydrolase activity membrane depolarization membrane hyperpolarization long-term synaptic potentiation positive regulation of ERK1 and ERK2 cascade protein kinase C signaling protein localization to plasma membrane neuron projection extension positive regulation of excitatory postsynaptic potential positive regulation of T-helper 2 cell cytokine production positive regulation of interleukin-5 secretion positive regulation of interleukin-13 secretion positive regulation of interleukin-10 secretion