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产品信息
H00005626-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PROP1 (NP_006252.1, 1 a.a. approximately 226 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.39 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MEAERRRQAE KPKKGRVGSS LLPERHPATG TPTTTVDSSA PPCRRLPGAG GGRSRFSPQG GQRGRPHSRR RHRTTFSPVQ LEQLESAFGR NQYPDIWARE SLARDTGLSE ARIQVWFQNR RAKQRKQERS LLQPLAHLSP AAFSSFLPES TACPYSYAAP PPPVTCFPHP YSHALPSQPS TGGAFALSHQ SEDWYPTLHP APAGHLPCPP PPPMLPLSLE PSKSWN
靶标信息
PROP1 encodes a paired-like homeodomain transcription factor in the developing pituitary gland. Expression occurs prior to and is required for expression of pou domain transcription factor 1, which is responsible for pituitary development and hormone expression. Mutations in this gene have been associated with combined pituitary hormone deficiency-2 as well as deficiencies in luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, and thyroid-stimulating hormone.
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生物信息学
蛋白别名: Homeobox protein prophet of Pit-1; Pituitary-specific homeodomain factor; PROP-1; prophet of Pit1, paired-like homeodomain transcription factor
基因别名: CPHD2; PROP-1; PROP1
UniProt ID: (Human) O75360
Entrez Gene ID: (Human) 5626
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
chromatin binding
protein binding
beta-catenin binding
protein C-terminus binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
blood vessel development
transcription from RNA polymerase II promoter
central nervous system development
dorsal/ventral pattern formation
cell migration
hypothalamus cell differentiation
negative regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
hypophysis morphogenesis
canonical Wnt signaling pathway
somatotropin secreting cell differentiation
