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Recommended positive controls: NT2D1, IMR32, U87-MG.
Predicted reactivity: Rat (92%), Chicken (83%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Phosphoribosyl transferase domain containing 1 (PRTFDC1) is highly homologous to the hypoxanthine phosphoribosyltransferase (HPRT1) and may have arisen from a gene duplication event of a common ancestor gene. Recently, it was shown that CpG islands in the PRTFDC1 promoter could be hypermethylated in ovarian cancers and oral squamous-cell carcinomas (OSCC), leading to gene silencing. Restoration of PRTFDC1 expression in OSCC inhibited cell growth in colony-formation assays, while knockdown of PRTFDC1 expression in OSCC that expressed the gene promoted cell growth. These results suggest that PRTFDC1 can act as a tumor-suppressor gene. At least three isoforms of PRTFDC1 are known to exist.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Phosphoribosyltransferase domain-containing protein 1
基因别名: HHGP; PRTFDC1
UniProt ID: (Human) Q9NRG1
Entrez Gene ID: (Human) 56952
分子生物学功能: glycosyltransferase