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Immunogen sequence: RTLTHEHLAM TFDCCYCPPP PCQEAISKEP IVMKNLYWIQ KNAYSHKENL QLNQETEAIK EELLYFKANG GGALVENTTT G
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 81%.
PTER is a mammalian homolog to bacterial phosphotriesterases, enzymes that hydrolyze phosphotriester-containing organophosphate pesticides. It is expressed primarily in the proximal renal tubules and the gene has been localized in humans to chromosomal band 10p12 by in situ hybridization. PTER, in addition to FTO, MC4R, and NPC1 has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. At least two isoforms of PTER are known to exist.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: hPHRP; Parathion hydrolase-related protein; Phosphotriesterase-related protein; resiniferatoxin-binding, phosphotriesterase-related
基因别名: HPHRP; PTER; RPR-1
UniProt ID: (Human) Q96BW5
Entrez Gene ID: (Human) 9317
分子生物学功能:
esterase
hydrolase
metabolite interconversion enzyme