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PTGDS Antibody (PA5-95977) in WB
Western blot analysis of PTGDS in extracts of Mouse heart. Samples were incubated with PTGDS Polyclonal antibody (Product # PA5-95977) using a dilution of 1:500, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
产品信息
PA5-95977
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 23-190 of human PTGDS (NP_0009453)
偶联物
形式
Liquid
浓度
0.19 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2807779
产品详细信息
Immunogen sequence: APEAQVSVQP NFQQDKFLGR WFSAGLASNS SWLREKKAAL SMCKSVVAPA TDGGLNLTST FLRKNQCETR TMLLQPAGSL GSYSYRSPHW GSTYSVSVVE TDYDQYALLY SQGSKGPGED FRMATLYSRT QTPRAELKEK FTAFCKAQGF TEDTIVFLPQ TDKCMTEQ; Positive Samples: Mouse heart; Cellular Location: Cytoplasm, Golgi apparatus, Nucleus membrane, Rough endoplasmic reticulum, perinuclear region
靶标信息
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. PTGDS has also been implicated in the development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement (NREM) sleep. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. PTGDS is the most abundant protein in the cerebral spinal fluid and recent evidence suggests that PTGDS acts as a Beta-Amyloid chaperone and may have a role in the deposition of Ab plaques in Alzheimer's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beta-trace protein; Cerebrin-28; Glutathione-independent PGD synthase; glutathione-independent PGD synthetase; L-PGDS; lipocalin-type prostaglandin D synthase; Lipocalin-type prostaglandin-D synthase; PGD2 synthase; PGDS; PGDS2; Prostaglandin D synthase; prostaglandin D2 synthase (21 kDa, brain); prostaglandin D2 synthase 21kDa (brain); Prostaglandin-D2 synthase; Prostaglandin-H2 D-isomerase; testis tissue sperm-binding protein Li 63n
基因别名: 21kDa; L-PGDS; LPGDS; PDS; PGD2; PGDS; PGDS2; PH2DISO; PTGDS; Ptgs3
UniProt ID: (Human) P41222, (Mouse) O09114, (Rat) P22057
Entrez Gene ID: (Human) 5730, (Mouse) 19215, (Rat) 25526
prostaglandin biosynthetic process
transport
cyclooxygenase pathway
regulation of circadian sleep/wake cycle, sleep
response to glucocorticoid
negative regulation of male germ cell proliferation
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
prostaglandin metabolic process
