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产品信息
PA5-42564
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human PTGIS
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2607688
产品详细信息
Peptide sequence: EIYTDPEVFK YNRFLNPDGS EKKDFYKDGK RLKNYNMPWG AGHNHCLGRS
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 93%; Rat: 100%; Zebrafish: 85%
靶标信息
CYP8A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cytochrome P450, family 8, subfamily A, polypeptide 1; Hydroperoxy icosatetraenoate dehydratase; MGC126858; MGC126860; Prostacyclin synthase; Prostaglandin I2 synthase
基因别名: CYP8; CYP8A1; PGIS; PTGI; PTGIS
UniProt ID: (Human) Q16647
Entrez Gene ID: (Human) 5740
prostaglandin biosynthetic process
icosanoid metabolic process
nicotinamide metabolic process
embryo implantation
cyclooxygenase pathway
negative regulation of NF-kappaB transcription factor activity
positive regulation of peroxisome proliferator activated receptor signaling pathway
negative regulation of nitric oxide biosynthetic process
positive regulation of angiogenesis
decidualization
negative regulation of inflammatory response
oxidation-reduction process
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to hypoxia
apoptotic signaling pathway
positive regulation of execution phase of apoptosis
