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PTHLH Antibody (500-P276-1MG) in WB
Western Blot: To detect Human PTHrP by Western Blot analysis PTHLH Polyclonal Antibody (Product # 500-P276-1MG) can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human PTHrP is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
产品信息
500-P276-1MG
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived Recombinant Human PTHrP
偶联物
形式
Lyophilized
浓度
0.1-1.0 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
RRID
AB_2930201
产品详细信息
AA Sequence of recombinant protein: AVSEHQLLHD KGKSIQDLRR RFFLHHLIAE IHTAEIRATS EVSPNSKPSP NTKNHPVRFG SDDEGRYLTQ ETNKVETYKE QPLKTP.
Preparation: Produced from sera of rabbits immunized with highly pure Recombinant Human PTHrP. Anti-Human PTHrP-specific antibody was purified by affinity chromatography employing an immobilized Human PTHrP matrix.
Sandwich ELISA: To detect Human PTHrP by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.5-2.0 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human PTHrP (500-P276Bt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human PTHrP.
Western Blot: To detect Human PTHrP by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human PTHrP is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
靶标信息
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: osteostatin; parathyroid hormone related peptide; parathyroid hormone-like hormone preproprotein; Parathyroid hormone-like protein; parathyroid hormone-like related protein; Parathyroid hormone-related protein; PLP; PTH-related protein; PTH-rP
基因别名: BDE2; HHM; PLP; PTHLH; PTHR; PTHRP
UniProt ID: (Human) P12272
Entrez Gene ID: (Human) 5744
skeletal system development
osteoblast development
adenylate cyclase-activating G-protein coupled receptor signaling pathway
cell-cell signaling
female pregnancy
positive regulation of cell proliferation
negative regulation of cell proliferation
epidermis development
regulation of gene expression
positive regulation of cAMP biosynthetic process
negative regulation of chondrocyte differentiation
cAMP metabolic process
