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Invitrogen

PTP1B/PTPN2 Recombinant Rabbit Monoclonal Antibody (24GB1130)

说明书
实验方案
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说明书
实验方案
技术支持

产品信息

MA5-56940

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:5,000
-

流式细胞分析 (Flow)

1:2,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

24GB1130

抗原

A synthesized peptide derived from human PTP1B/PTPN2 (aa 11-66)

偶联物

Unconjugated

形式

Liquid

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Dry ice (international)

靶标信息

PTP1B (Protein Tyrosine Phosphatase 1B), encoded by the PTPN1 gene located on chromosome 20q13.1, is a major regulator of several cellular signaling pathways, impacting diseases like diabetes, obesity, and various cancers. The protein structure includes multiple exons and functions as a non-transmembrane enzyme that negatively regulates signaling cascades, including insulin and leptin signaling, which are vital for metabolic homeostasis. PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2), located on chromosome 18p11.3-p11.2, also known as T-cell PTP, is similarly a non-transmembrane protein tyrosine phosphatase that modulates immune responses and cell growth. It has ten exons and produces two splice variants, impacting signaling pathways by regulating the phosphorylation state of key proteins. Both of these phosphatases are involved in the fine-tuning of signaling mechanisms that control cell growth, differentiation, and immune regulation, highlighting their importance in disease pathology and as potential therapeutic targets.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: MPTP; protein tyrosine phosphatase 1B; protein tyrosine phosphatase, placental; protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase PTP-2; Protein-tyrosine phosphatase PTP-S; PTP-1B; PTP-HA2; PTP1B; T cell protein-tyrosine phosphatase; T-cell protein tyrosine phosphatase; T-cell protein-tyrosine phosphatase; TCPTP; Tyrosine-protein phosphatase non-receptor type 1; Tyrosine-protein phosphatase non-receptor type 2

基因别名: AI325124; PTN2; Ptp; PTP-1B; PTP-HA2; PTP1B; PTPN1; PTPN2; PTPT; TC-PTP; TCELLPTP; TCPTP

UniProt ID: (Human) P18031, (Human) P17706, (Rat) P20417, (Mouse) P35821, (Mouse) Q06180, (Rat) P35233

Entrez Gene ID: (Human) 5770, (Human) 5771, (Rat) 24697, (Mouse) 19246, (Mouse) 19255, (Rat) 117063

功能
protein tyrosine phosphatase activity insulin receptor binding protein binding zinc ion binding enzyme binding protein kinase binding receptor tyrosine kinase binding poly(A) RNA binding ephrin receptor binding protein phosphatase 2A binding cadherin binding involved in cell-cell adhesion non-membrane spanning protein tyrosine phosphatase activity integrin binding syntaxin binding phosphoprotein phosphatase activity hydrolase activity phosphatase activity DNA binding protein phosphatase
参与通路
protein dephosphorylation activation of signaling protein activity involved in unfolded protein response activation of JUN kinase activity insulin receptor signaling pathway regulation of signal transduction negative regulation of signal transduction regulation of endocytosis negative regulation of vascular endothelial growth factor receptor signaling pathway endoplasmic reticulum unfolded protein response actin cytoskeleton reorganization regulation of intracellular protein transport peptidyl-tyrosine dephosphorylation platelet-derived growth factor receptor-beta signaling pathway IRE1-mediated unfolded protein response negative regulation of MAP kinase activity negative regulation of insulin receptor signaling pathway regulation of type I interferon-mediated signaling pathway JAK-STAT cascade involved in growth hormone signaling pathway positive regulation of protein tyrosine kinase activity negative regulation of ERK1 and ERK2 cascade cell-cell adhesion regulation of hepatocyte growth factor receptor signaling pathway negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of IRE1-mediated unfolded protein response negative regulation of PERK-mediated unfolded protein response peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity positive regulation of receptor catabolic process negative regulation of cell proliferation negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of lipid storage B cell differentiation T cell differentiation erythrocyte differentiation negative regulation of epidermal growth factor receptor signaling pathway negative regulation of tyrosine phosphorylation of Stat1 protein negative regulation of tyrosine phosphorylation of Stat5 protein negative regulation of tyrosine phosphorylation of Stat6 protein glucose homeostasis negative regulation of macrophage differentiation positive regulation of gluconeogenesis negative regulation of inflammatory response negative regulation of T cell receptor signaling pathway negative regulation of chemotaxis regulation of interferon-gamma-mediated signaling pathway negative regulation of interferon-gamma-mediated signaling pathway negative regulation of type I interferon-mediated signaling pathway negative regulation of protein tyrosine kinase activity negative regulation of interleukin-6-mediated signaling pathway negative regulation of interleukin-2-mediated signaling pathway negative regulation of prolactin signaling pathway negative regulation of interleukin-4-mediated signaling pathway negative regulation of macrophage colony-stimulating factor signaling pathway negative regulation of positive thymic T cell selection positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of PERK-mediated unfolded protein response negative regulation of platelet-derived growth factor receptor-beta signaling pathway regulation of insulin receptor signaling pathway dephosphorylation response to endoplasmic reticulum stress negative regulation of tyrosine phosphorylation of Stat3 protein
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