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Invitrogen
PTPLAD1 Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
产品信息
PA5-53239
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2646119
产品详细信息
Immunogen sequence: MENQVLTPHV YWAQRHRELY LRVELSDVQN PAISITENVL HFKAQGHGAK GDNVYEFHLE FLDLVKPEPV YKLTQRQVNI TVQKKVSQWW ERLTKQEKRP LFLAPDFDRW LDESDAEMEL RAKEEERLNK LRLE
Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.
靶标信息
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3-hydroxyacyl-CoA dehydratase 3; B-ind1; Butyrate-induced protein 1; butyrate-induced transcript 1; HACD3; protein tyrosine phosphatase-like A domain containing 1; protein tyrosine phosphatase-like protein PTPLAD1; Protein-tyrosine phosphatase-like A domain-containing protein 1; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3; Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
基因别名: B-IND1; BIND1; HACD3; HSPC121; PTPLAD1
UniProt ID: (Human) Q9P035
Entrez Gene ID: (Human) 51495
I-kappaB kinase/NF-kappaB signaling
activation of JUN kinase activity
small GTPase mediated signal transduction
Rho protein signal transduction
Rac protein signal transduction
fatty acid elongation
very long-chain fatty acid biosynthetic process
positive regulation of GTPase activity
positive regulation of viral genome replication
positive regulation by virus of viral protein levels in host cell
