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产品信息
H00026191-B01P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PTPN22 (AAH71670.1, 1 a.a. approximately 752 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE KPKNIKKNRY KDILPYDYSR VELSLITSDE DSSYINANFI KGVYGPKAYI ATQGPLSTTL LDFWRMIWEY SVLIIVMACM EYEMGKKKCE RYWAEPGEMQ LEFGPFSVSC EAEKRKSDYI IRTLKVKFNS ETRTIYQFHY KNWPDHDVPS SIDPILELIW DVRCYQEDDS VPICIHCSAG CGRTGVICAI DYTWMLLKDG SQAKHCIPEK NHTLQADSYS PNLPKSTTKA AKMMNQQRTK MEIKESSSFD FRTSEISAKE ELVLHPAKSS TSFDFLELNY SFDKNADTTM KWQTKAFPIV GEPLQKHQSL DLGSLLFEGC SNSKPVNAAG RYFNSKVPIT RTKSTPFELI QQRETKEVDS KENFSYLESQ PHDSCFVEMQ AQKVMHVSSA ELNYSLPYDS KHQIRNASNV KHHDSSALGV YSYIPLVENP YFSSWPPSGT SSKMSLDLPE KQDGTVFPSS LLPTSSTSLF SYYNSHDSLS LNSPTNISSL LNQESAVLAT APRIDDEIPP PLPVRTPESF IVVEEAGEFS PNVPKSLSSA VKVKIGTSLE WGGTSEPKKF DDSVILRPSK SVKLRSPKSE LHQDRSSPPP PLPERTLESF FLADEDCMQA QSIETYSTSY PDTMENSTSS KQTLKTPGKS FTRSKSLKIL RNMKKSICNS CPPNKPAESV QSNNSSSFLN FGFANRFSKP KGPRNPPPTW NI
靶标信息
The protein tyrosine phosphatase PTPN22 (PTP22, LYP, PEP, formerly PTPN8) is a genetic variant that confers risk of developing diverse human autoimmune diseases such as type 1 diabetes and rheumatoid arthritis. The minor allele of a missense SNP in PTPN22 encodes a hematopoietic-specific protein tyrosine phosphatase also known as "Lyp." The risk allele is present in about 17% of Caucasian individuals from the general population and in approximately 28% of Caucasian individuals with rheumatoid arthritis; it is thought to disrupt the P1 proline-rich motif that is important for interaction with the Src homology-3 (SH3) domain of CSK (cytoplasmic tyrosine kinase), potentially altering the normal functions of these proteins as negative regulators of T cell activation. The interaction between CSK and PTPN22 is highly specific and it is speculated that PTPN22 may be an effector and/or regulator of CSK in T cells and other hematopoietic cells.
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生物信息学
蛋白别名: Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; lymphoid-specific protein tyrosine phosphatase; LyP; PEP; PEST-domain phosphatase; protein tyrosine phosphatase, non-receptor type 22 (lymphoid); protein tyrosine phosphatase, non-receptor type 8; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 22
基因别名: LYP; LYP1; LYP2; PEP; PTPN22; PTPN8
UniProt ID: (Human) Q9Y2R2
Entrez Gene ID: (Human) 26191
protein dephosphorylation
autophagy
negative regulation of autophagy
positive regulation of gene expression
negative regulation of gene expression
T cell differentiation
lipopolysaccharide-mediated signaling pathway
positive regulation of type I interferon production
response to lipopolysaccharide
negative regulation of tumor necrosis factor production
regulation of natural killer cell proliferation
positive regulation of toll-like receptor 3 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
peptidyl-tyrosine dephosphorylation
phosphoanandamide dephosphorylation
negative regulation of JUN kinase activity
regulation of innate immune response
regulation of B cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
positive regulation of ERK1 and ERK2 cascade
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
cellular response to muramyl dipeptide
negative regulation of interleukin-6 secretion
regulation of NIK/NF-kappaB signaling
positive regulation of protein K63-linked ubiquitination
positive regulation of interferon-gamma secretion
negative regulation of p38MAPK cascade
negative regulation of interleukin-8 secretion
