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This antibody detects endogenous protein at a molecular weight of 65 kDa.
Purity is >95% by SDS-PAGE.
Protein tyrosine phosphatases, or PTPs, are type I transmembrane proteins, membrane associated proteins or proteins localized in nuclei. Examples of transmembrane PTPs are LAR, PTP alpha, PTP beta, PTP gamma, PTP delta, PTP epsilon, PTP zeta, PTPk and PTP-mu. Transmembrane PTPs play diverse roles during development and in adult tissues. Immunodepletion studies have suggested LAR to be a regulator of Insulin receptor phosphorylation. PTP alpha activity is increased twofold in response to phorbol ester stimulation, resulting in serine phosphorylation either directly or indirectly by members of the PKC family. Overexpression of v-H-ras and Neu, but not Myc or Int2, in mammary tumors has been shown to induce PTP epsilon expression. An alternative splicing event leads to a nervous tissue-specific chondroitin sulfate proteoglycan called phosphacan, which represents the amino terminal portion of PTP zeta. PTPk and PTP-mu share a conserved amino terminal 160 amino acid MAM domain which facilitates homophilic binding. PTP-mu localizes to points of cell contact and may be involved in regulating the assembly and disassembly of cadherin/catenin complexes in vivo.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa , protein tyrosine phosphatase kappa; protein tyrosine phosphatase, receptor type, K; protein tyrosine phosphatase, receptor type, K, extracellular region; Protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase, receptor type, kappa; R-PTP-k; R-PTP-kappa; R-PTPk; receptor-like protein tyrosine phosphatase kappa extracellular region (RPTPK); Receptor-type tyrosine-protein phosphatase kappa
基因别名: AI853699; PTPK; PTPRK; R-PTP-kappa; Rptpk; RPTPkappa
UniProt ID: (Human) Q15262, (Mouse) P35822
Entrez Gene ID: (Human) 5796, (Mouse) 19272, (Rat) 360302
分子生物学功能:
extracellular matrix glycoprotein
protein phosphatase
protein modifying enzyme