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Immunogen sequence: TNRGSSLGGL QQTVTAWTAF NLLNGKPSVA PKPDADGFIM VYLPDGQSPV PVQSYFIVMV PLRKSRGGQF LTPLGSPEDM DLEELIQDIS RLQRRSLRHS RQLEVPRPYI AARFSVLPPT FHPGDQKQYG GFDNRGLEPG HRYVLFVLAV LQKSEPTFAA SPFSDPFQLD NPDPQPIVDG E; Positive Samples: Rat testis; Cellular Location: Membrane, Single-pass type I membrane protein
PTPRS cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: LAR-PTP2; Leukocyte common antigen-related protein-tyrosine phosphatase 2; leukocyte common antigen-related proten-tyrosine phosphatase 2; protein tyrosine phosphatase, receptor type, D; R-PTP-S; R-PTP-sigma; Receptor-type tyrosine-protein phosphatase S; Receptor-type tyrosine-protein phosphatase sigma
基因别名: Larptp2; Ptprd; Ptprs; Ptpsigma; Ptpsigma.; Rptpd
UniProt ID: (Rat) Q64605
Entrez Gene ID: (Rat) 25529