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产品信息
PA5-34475
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 17 amino acid peptide near the amino terminus of human PANX1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2551827
产品详细信息
A suggested positive control is human ovary tissue lysate.
PA5-34475 can be used with blocking peptide PEP-1517.
靶标信息
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: innexin; Pannexin-1; PANX1
基因别名: AI847747; MRS1; PANX1; PX1; UNQ2529; UNQ2529/PRO6028
UniProt ID: (Human) Q96RD7, (Rat) P60570, (Mouse) Q9JIP4
Entrez Gene ID: (Human) 24145, (Rat) 315435, (Mouse) 55991
protease binding
receptor binding
calcium channel activity
leak channel activity
ion channel binding
protein heterodimerization activity
actin filament binding
gap junction hemi-channel activity
scaffold protein binding
actin binding
gap junction channel activity
protein binding
channel activity
wide pore channel activity
response to ischemia
cation transport
calcium ion transport
cell-cell signaling
response to ATP
protein hexamerization
positive regulation of cytokine secretion
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
transmembrane transport
calcium ion transmembrane transport
transport
ion transport
