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Par4 Antibody (A302-092A) in WB
Detection of human Par4 by western blot and immunoprecipitation. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Par4 antibody (Product # A302-092A) used for IP at 3 µg/mg lysate. Par4 was also immunoprecipitated by rabbit anti-Par4 antibody A302-091A, which recognizes an upstream epitope. For blotting immunoprecipitated Par4, A302-091A was used at 1 µg/mL. Detection: Chemiluminescence with an exposure time of 10 seconds.
产品信息
A302-092A
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Region between residue 290 and 340 of human prostate apoptosis response protein 4 (PRKC, apoptosis, WT1, regulator).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris citrate/phosphate, pH 7-8
内含物
0.09% sodium azide
保存条件
4° C
运输条件
Wet ice
产品详细信息
The recommended shelf life for this product is 1 year from date of receipt.^M
^M
Based on 100% sequence identity, this antibody is predicted to react with Mouse and Rat
靶标信息
This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Par-4; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; prostate apoptosis response 4; Prostate apoptosis response 4 protein; prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; transcriptional repressor PAR4; WT1-interacting protein
基因别名: Par-4; PAR4; PAWR
UniProt ID: (Human) Q96IZ0
Entrez Gene ID: (Human) 5074
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
apoptotic process
response to wounding
response to iron(II) ion
negative regulation of B cell proliferation
response to lipopolysaccharide
positive regulation of phosphoprotein phosphatase activity
interleukin-2 biosynthetic process
negative regulation of T cell proliferation
positive regulation of amyloid precursor protein biosynthetic process
positive regulation of apoptotic process
positive regulation of neuron apoptotic process
negative regulation of T cell receptor signaling pathway
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
actin filament bundle assembly
positive regulation of hindgut contraction
cellular response to vitamin E
cellular response to interleukin-1
cellular response to follicle-stimulating hormone stimulus
cellular response to estradiol stimulus
negative regulation of calcium ion import
apoptotic signaling pathway
activation of cysteine-type endopeptidase activity
positive regulation of relaxation of smooth muscle
positive regulation of leukocyte tethering or rolling
positive regulation of neuronal action potential
calcium ion import into cell
positive regulation of neutrophil extravasation
