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Parvalbumin Antibody (PA5-18389) in WB
Western blot analysis of Parvalbumin using Parvalbumin Polyclonal Antibody (Product # PA5-18389) (0.01 µg/mL) in staining of Human Cerebellum (A) lysate + peptide (B) and (0.3 µg/mL) Rat Brain (C) lysate + peptide (D) (35 µg protein in RIPA buffer). Detected by chemiluminescence.
产品信息
PA5-18389
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
已发表种属
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (GVDEFSTLVAES) corresponding to the C-terminus amino acids of PVALB
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10977301
产品详细信息
This antibody is tested in Peptide ELISA: antibody detection limit dilution 64,000.
靶标信息
Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: HGNC:9704; MGC116759; Parvalbumin (calcium binding protein); Parvalbumin alpha
基因别名: D22S749; PALB1; Pva; PVALB
UniProt ID: (Human) P20472, (Rat) P02625
Entrez Gene ID: (Human) 5816, (Rat) 25269
