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Invitrogen
Parvalbumin Polyclonal Antibody
高级验证
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
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Parvalbumin Antibody (PA5-96209) in IHC (P)
Immunohistochemistry analysis of Parvalbumin in paraffin-embedded rat brain. Samples were incubated with Parvalbumin Polyclonal antibody (Product # PA5-96209) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-96209
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human Parvalbumin (PVALB) (NP_0028451)
偶联物
形式
Liquid
浓度
0.38 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.09% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808011
产品详细信息
Positive Samples: Mouse skeletal muscle
Immunogen sequence: MSMTDLLNAE DIKKAVGAFS ATDSFDHKKF FQMVGLKKKS ADDVKKVFHM LDKDKSGFIE EDELGFILKG FSPDARDLSA KETKMLMAAG DKDGDGKIGV DEFSTLVAES
靶标信息
Parvalbumin (PV) is a calcium binding protein expressed in specific muscle fibers and fast-firing neurons. PV consists of a single, unbranched chain of linked amino acids and belongs to a larger group of EF hand proteins. Studies have demonstrated that parvalbumin acts in the decay of calcium in the contraction/ relaxation cycle of fast twitch muscles. This data has shown a positive correlation between the rate of relaxation and the concentration of parvalbumin. Parvalbumin is also expressed in a specific population of GABAergic interneurones which are thought to play a role in maintaining the balance between excitation and inhibition in the cortex as well as the hippocampus. In amyotrophic lateral sclerosis (ALS) patents, parvalbumin immunoreactivity is specifically absent from neuron populations lost early in ALS.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: HGNC:9704; MGC116759; Parvalbumin (calcium binding protein); Parvalbumin alpha
基因别名: D22S749; PALB1; Parv; PV; Pva; PVALB
UniProt ID: (Human) P20472, (Rat) P02625, (Mouse) P32848
Entrez Gene ID: (Human) 5816, (Rat) 25269, (Mouse) 19293
