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Peptidylarginine Deiminase Antibody (PA5-64014) in ICC/IF
Immunofluorescent staining of Peptidylarginine Deiminase in human cell line HaCaT using a Peptidylarginine Deiminase Polyclonal Antibody (Product # PA5-64014) shows localization to cytosol.
产品信息
PA5-64014
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2645389
产品详细信息
Immunogen sequence: PSACLKLFQE KKEEGYGEAA QFDGLKHQAK RSINEMLADR HLQRDNLHAQ KCIDWN
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 82%.
靶标信息
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hPAD-colony 10; PADI5; PDI2; PDI3; PDI4; peptidyl arginine deiminase, type I; Peptidylarginine deiminase I; Protein-arginine deiminase type I; Protein-arginine deiminase type-1
基因别名: HPAD10; PAD1; PADI1; PDI; PDI1
UniProt ID: (Human) Q9ULC6
Entrez Gene ID: (Human) 29943
