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Periostin Antibody (MA5-32701) in IHC (P)
Immunohistochemistry analysis of Periostin with paraffin-embedded human skin. The tissues were blocked in 1% BSA (30 min, room temp), washed with ddH2O and PBS, incubated with recombinant monoclonal Periostin (Product # MA5-32701) at a dilution of 1:400 (30 min, room temperature). Detection was performed with HRP, DAB was used as the chromogen, counterstained with hematoxylin and mounted with DPX.
产品信息
MA5-32701
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JA63-40
抗原
Synthetic pepride within Human Perilipin-1 aa 11-60
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2809978
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for alpha(V)beta(3) and alpha(V)beta(5) integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1(TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: fasciclin I-like; Fasciclin-I like; MGC119510; MGC119511; OSF 2; OSF-2; osteoblast specific factor 2; osteoblast specific factor 2 (fasciclin I-like); Osteoblast-specific factor 2; periodontal ligament-specific periostin; Periostin; periostin, osteoblast specific factor; PN; RP11 412K4.1; RP11-412K4.1
基因别名: OSF-2; OSF2; PDLPOSTN; PN; POSTN
UniProt ID: (Human) Q15063
Entrez Gene ID: (Human) 10631
skeletal system development
response to hypoxia
negative regulation of cell-matrix adhesion
regulation of systemic arterial blood pressure
cell adhesion
regulation of Notch signaling pathway
response to mechanical stimulus
response to muscle activity
positive regulation of smooth muscle cell migration
extracellular matrix organization
response to estradiol
cellular response to fibroblast growth factor stimulus
cellular response to vitamin K
cellular response to tumor necrosis factor
cellular response to transforming growth factor beta stimulus
negative regulation of substrate adhesion-dependent cell spreading
positive regulation of chemokine (C-C motif) ligand 2 secretion
neuron projection extension
bone regeneration
