Invitrogen

Phospho-Amyloid Precursor Protein (Thr743) Polyclonal Antibody

Phospho-Amyloid Precursor Protein (Thr743) Antibody in Immunocytochemistry (ICC/IF)

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Phospho-Amyloid Precursor Protein (Thr743) Antibody (PA5-37477) in ICC/IF

Immunocytochemical analysis of Phospho-Amyloid Precursor Protein (Thr743) in methanol-fixed Hela cells, using Phospho-Amyloid Precursor Protein (Thr743) Polyclonal Antibody (Product # PA5-37477).

Phospho-Amyloid Precursor Protein (Thr743) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

PA5-37477

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

1:50-1:100

免疫细胞化学 (ICC/IF)

1:100-1:200

产品规格

种属反应

Human, Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide sequence around phosphorylation site of threonine 743 (A-V-T(p)-P-E) derived from human Amyloid Precursor Protein (APP).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2554086

产品详细信息

A suggested positive control for Western blot is COS7 cells; suggested positive control for IHC is human brain tissue; suggested positive control for ICC/IF is Hela cells.

靶标信息

Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer's disease. Abnormal regulation and processing of APP also plays a role in Down's syndrome, early onset familial Alzheimer's disease, and cerebral hemorrhage.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ABPP; AG; Alzheimer disease amyloid A4 protein homolog; Alzheimer disease amyloid protein; amyloid A4; Amyloid b precursor protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; Amyloid precursor protein; Amyloid β precursor protein; Amyloid-beta (A4) precursor protein; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloidogenic glycoprotein; APP; APPI; appican; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; Cerebral vascular amyloid peptide; CVAP; Pan-Abeta; peptidase nexin-II; PN-II; PreA4; protease nexin II; Protease nexin-II; testicular tissue protein Li 2

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基因别名: A4; AAA; ABETA; ABPP; AD1; Adap; Ag; APP; APPI; betaApp; CTFgamma; CVAP; E030013M08Rik; PN-II; PN2

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UniProt ID: (Human) P05067, (Rat) P08592, (Mouse) P12023

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Entrez Gene ID: (Human) 351, (Rat) 54226, (Mouse) 11820

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