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Invitrogen
Phospho-CDK1 (Thr14, Tyr15) Recombinant Rabbit Monoclonal Antibody (17H29L7)
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
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Phospho-CDK1 (Thr14, Tyr15) Antibody (701808) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized A375 cells which were serum starved (19 hours) and serum released (24 hours), for detection of Cdk1 (pTpY14/15) using Anti- Cdk1 (pTpY14/15) Recombinant Rabbit Monoclonal Antibody (Product # 701808, 1-2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). ... View More
产品信息
701808
产品规格
种属反应
Human
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
17H29L7
抗原
Phosphorylated peptide corresponding to Human CDK1 (aa 11-19)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2609690
产品详细信息
This antibody is predicted to react with Monkey, Rat, Mouse, Rabbit, Bovine, Pig and Feline.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ABL1; CDK1; cell cycle controller CDC2; Cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; Cell division protein kinase 1; Cyclin-dependent kinase 1; DKFZp686L20222; MGC111195; MGC53829; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase
基因别名: CDC2; CDC28A; CDK1; CDKN1; P34CDC2
UniProt ID: (Human) P06493
Entrez Gene ID: (Human) 983
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
cyclin binding
Hsp70 protein binding
histone kinase activity
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
activation of MAPK activity
microtubule cytoskeleton organization
DNA replication
DNA repair
protein complex assembly
apoptotic process
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
mitotic nuclear division
mitotic nuclear envelope disassembly
mitotic G2 DNA damage checkpoint
centrosome cycle
pronuclear fusion
cell aging
response to toxic substance
positive regulation of gene expression
regulation of Schwann cell differentiation
response to organic cyclic compound
response to amine
response to activity
cell migration
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
chromosome condensation
epithelial cell differentiation
organ regeneration
anaphase-promoting complex-dependent catabolic process
positive regulation of protein import into nucleus, translocation
protein localization to kinetochore
response to drug
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
response to ethanol
positive regulation of DNA replication
positive regulation of mitotic cell cycle
regulation of embryonic development
response to cadmium ion
response to copper ion
response to axon injury
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
ventricular cardiac muscle cell development
positive regulation of cardiac muscle cell proliferation
cellular response to hydrogen peroxide
Golgi disassembly
positive regulation of protein localization to nucleus
