Invitrogen

Phospho-CSF1R (Tyr723) Monoclonal Antibody (F.540.2)

Phospho-CSF1R (Tyr723) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Phospho-CSF1R (Tyr723) Antibody (MA5-15151) in IHC (P)

Immunohistochemical analysis of Phospho-M-CSF Receptor pTyr723 in paraffin-embedded FDCP1/fms cells, untreated (left) or mCSF-treated (right), using a Phospho-M-CSF Receptor pTyr723 monoclonal antibody (Product # MA5-15151).

Phospho-CSF1R (Tyr723) Antibody in Western Blot (WB)

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产品信息

MA5-15151

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:300

免疫沉淀 (IP)

1:200

产品规格

种属反应

Human, Mouse

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Monoclonal

类型

Antibody

克隆号

F.540.2

抗原

Synthetic phosphopeptide corresponding to residues surrounding pTyr723 of human M-CSF receptor

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

228 µg/mL

纯化类型

Affinity chromatography

保存液

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

内含物

<0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_10985855

产品详细信息

It is not recommended to aliquot this antibody.

This antibody is not cross-reactive with related active protein tyrosine kinases.

靶标信息

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Anti-angiogenic therapy using the multi-tyrosine kinase inhibitor Regorafenib enhances tumor progression in a transgenic mouse model of ß-cell carcinogenesis.

British journal of cancer

Egidi MJ,Krug S,Haybaeck J,Michl P,Griesmann H

MA5-15151 was used in Western Blot to identify important tumor cell-autonomous and stroma-dependent mechanisms of resistance to antiangiogenic therapies.

Sun Oct 01 00:00:00 EDT 2023

Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.

Proceedings of the National Academy of Sciences of the United States of America

Kim SM,Taneja C,Perez-Pena H,Ryu V,Gumerova A,Li W,Ahmad N,Zhu LL,Liu P,Mathew M,Korkmaz F,Gera S,Sant D,Hadelia E,Ievleva K,Kuo TC,Miyashita H,Liu L,Tourkova I,Stanley S,Lizneva D,Iqbal J,Sun L,Tamler R,Blair HC,New MI,Haider S,Yuen T,Zaidi M

MA5-15151 was used in Immunohistochemistry to report that two widely-used drugs for erectile dysfunction, tadalafil and vardenafil, trigger bone gain in mice through a combination of anabolic and antiresorptive actions on the skeleton.

Tue Jun 23 00:00:00 EDT 2020

生物信息学

蛋白别名: c-fms; CD115; CD115 antigen; CSF-1 receptor; CSF-1-R; CSFIR; EC 2.7.10.1; FMS proto-oncogene; kinase CSFR; macrophage colony stimulating factor I receptor; Macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; OTTHUMP00000224093; Proto-oncogene c-Fms; proto-oncogene fms

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基因别名: AI323359; C-FMS; CD115; CSF-1R; CSF1R; Csfmr; CSFR; Fim-2; FIM2; FMS; HDLS; M-CSF-R; M-CSFR

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UniProt ID: (Human) P07333, (Mouse) P09581

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Entrez Gene ID: (Human) 1436, (Mouse) 12978

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功能