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Phospho-EphB1/EphB3/EphB4 (Tyr778, Tyr792, Tyr774) Polyclonal Antibody detects endogenous levels of EphB1/EphB3/EphB4 only when phosphorylated at Tyr778, Tyr792, Tyr774.
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Developmental kinase 2; Developmental kinase 5; EK2; EK6; ELK; ELK-related protein tyrosine kinase; Embryonic kinase 2; Eph receptor B2 (ELK-related protein tyrosine kinase); EPH receptor B4; EPH tyrosine kinase 2; EPH-like kinase 2; EPH-like kinase 6; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; ephrin receptor EphB4; Ephrin type-B receptor 1; Ephrin type-B receptor 3; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; human embryo kinase 2; mDK-2; mDK-5; NET; Neuronally-expressed EPH-related tyrosine kinase; soluble EPHB1 variant 1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyrosine kinase MYK-1; Tyrosine-protein kinase receptor EPH-2; tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase receptor SEK-4; Tyrosine-protein kinase TYRO11; Tyrosine-protein kinase TYRO6
基因别名: 9330129L11; AI042935; AW456895; AW488255; C130099E04Rik; Cek10; Cek6; EK2; ELK; Elkh; ENSMUSG00000074119; EPHB1; Ephb2; EPHB3; EPHB4; EPHT2; Epth2; Erk; ETK2; HEK2; HEK6; HTK; MDK2; MDK5; MYK1; NET; Sek4; TYRO11; TYRO6
UniProt ID: (Human) P54762, (Human) P54753, (Human) P54760, (Rat) P09759, (Mouse) Q8CBF3, (Mouse) P54754, (Mouse) P54761
Entrez Gene ID: (Human) 2047, (Human) 2049, (Human) 2050, (Rat) 24338, (Mouse) 270190, (Mouse) 13845, (Rat) 287989, (Rat) 686310, (Mouse) 13846
分子生物学功能:
transmembrane signal receptor