Invitrogen

Phospho-Ezrin (Tyr146) Polyclonal Antibody

查看其他27个Ezrin抗体
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说明书
实验方案
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产品信息

PA5-104801

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫细胞化学 (ICC/IF)

1:100-1:500
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human EZR(Accession P15311), corresponding to amino acid residues around phosphorylated Tyr146.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2816274

产品详细信息

Antibody detects endogenous levels of Ezrin only when phosphorylated at Tyrosine 146.

靶标信息

The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Cytovillin; cytovillin 2; DKFZp762H157; epididymis secretory protein Li 105; EZRI; Ezrin; FLJ26216; MGC1584; p81; villin 2; villin 2 (ezrin); Villin-2

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基因别名: AW146364; CVIL; CVL; EZR; HEL-S-105; p81; R75297; VIL2

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UniProt ID: (Human) P15311, (Mouse) P26040, (Rat) P31977

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Entrez Gene ID: (Human) 7430, (Mouse) 22350, (Rat) 54319

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功能
actin binding protein binding microtubule binding protein domain specific binding protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding S100 protein binding poly(A) RNA binding cell adhesion molecule binding actin filament binding ATPase binding cadherin binding involved in cell-cell adhesion cytoskeletal protein binding protein complex binding structural molecule activity actin or actin-binding cytoskeletal protein
参与通路
negative regulation of transcription from RNA polymerase II promoter intestinal D-glucose absorption sphingosine-1-phosphate signaling pathway cytoskeletal anchoring at plasma membrane leukocyte cell-cell adhesion axon guidance regulation of cell shape regulation of cell size positive regulation of gene expression protein kinase A signaling gland morphogenesis membrane to membrane docking microvillus assembly astral microtubule organization actin cytoskeleton reorganization receptor internalization regulation of microvillus length regulation of actin cytoskeleton organization cellular protein complex localization positive regulation of multicellular organism growth cortical microtubule organization establishment of epithelial cell apical/basal polarity filopodium assembly phosphatidylinositol-mediated signaling positive regulation of protein secretion negative regulation of T cell receptor signaling pathway actin filament bundle assembly establishment of centrosome localization establishment of endothelial barrier negative regulation of ERK1 and ERK2 cascade cellular response to cAMP protein localization to cell cortex establishment of protein localization to plasma membrane positive regulation of establishment of protein localization to plasma membrane negative regulation of interleukin-2 secretion regulation of NIK/NF-kappaB signaling regulation of organelle assembly terminal web assembly positive regulation of protein localization to early endosome positive regulation of cellular protein catabolic process negative regulation of p38MAPK cascade positive regulation of early endosome to late endosome transport establishment or maintenance of apical/basal cell polarity epithelial cell differentiation
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