Invitrogen

Phospho-GRK1/GRK2 (Tyr13) Polyclonal Antibody

产品信息

PA5-64755

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human GRK1/2 (Phospho-Tyr13)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2665189

产品详细信息

Phospho-GRK1/GRK2 (Tyr13) Polyclonal Antibody detects endogenous levels of GRK1/GRK2 only when phosphorylated at Tyr13.

靶标信息

The sensation of sight is the result of a cascade of events starting with the interaction of photoactivated rhodopsin with a protein called transducin. Rhodopsin kinase is a G-protein-coupled Ser/Thr kinase, also known as GRK1, which is a key element in the regulation of this cascade. Following phosphorylation by GRK1, arrestin is recruited to phospho-rhodopsin quenching its phototransductive activity by preventing further interaction with transducin. By breaking the cycle of phototransduction, GRK1 plays an important role in the restoration of the system for subsequent visual events.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; Beta-ARK-1; G protein-coupled receptor kinase 1; G protein-coupled receptpr kinase 1; G-protein coupled receptor kinase 2; G-protein receptor kinase 1; G-protein-coupled receptor kinase 2; grk 2; rhodopsin kinase; Rhodopsin kinase GRK1; RK

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基因别名: Adrbk-1; ADRBK1; BARK; Bark-1; BARK1; beta ARK; BETA-ARK1; betaARK1; GPRK1; GRK-2; GRK1; GRK2; RHOK; RK