7TM Antibodies

Phospho-Gastric Inhibitory Polypeptide Receptor (Ser433, Ser435) Polyclonal Antibody

Phospho-Gastric Inhibitory Polypeptide Receptor (Ser433, Ser435) Antibody in Western Blot (WB)

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Phospho-Gastric Inhibitory Polypeptide Receptor (Ser433, Ser435) Antibody (7TM0248B) in WB

Agonist-induced Serine433/Serine435 phosphorylation of GIPR. Upper panel, HEK293 cells stably expressing the GIP-Receptor (GIPR) were either not exposed or exposed to 1 µM of GIP receptor Agonist GIP for 30 minutes. Cells were lysed and immunoblotted with the anti-pS433/pS435-GIPR antibody (7TM0248B) at a dilution of 1:1,000. Lower panel, blot was stripped and reprobed with an phosphorylation-independent an... View More

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产品信息

7TM0248B

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic phosphopeptide derived from human GIPR around the phosphorylation site of Ser433/Ser435.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

Dulbecco's PBS, pH 7.4

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice (domestic); Dry ice (international)

靶标信息

GIPR encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes.

仅用于科研。不用于诊断过程。未经明确授权不得转售。