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Phospho-HCN1 (Ser846) Antibody (PA5-105316) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-HCN1 (Ser846) in human heart tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-HCN1 (Ser846) polyclonal antibody (Product # PA5-105316) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
产品信息
PA5-105316
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human HCN1(Accession O60741), corresponding to amino acid residues around phosphorylated Ser846.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2816744
产品详细信息
Antibody detects endogenous levels of HCN1 only when phosphorylated at Ser846.
靶标信息
HCN1 includes Hyperpolarization-activated cation channels of the HCN gene family, which contribute to spontaneous rhythmic activity in both heart and brain. HCN1 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BCNG-1; Brain cyclic nucleotide-gated channel 1; HAC-2; Hyperpolarization-activated cation channel 2; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
基因别名: BCNG-1; BCNG1; C630013B14Rik; EIEE24; HAC-2; HAC2; HCN1
UniProt ID: (Human) O60741, (Mouse) O88704, (Rat) Q9JKB0
Entrez Gene ID: (Human) 348980, (Mouse) 15165, (Rat) 84390
intracellular cAMP activated cation channel activity
voltage-gated sodium channel activity
voltage-gated potassium channel activity
potassium channel activity
cAMP binding
identical protein binding
nucleotide binding
ion channel activity
voltage-gated ion channel activity
sodium channel activity
protein binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
protein C-terminus binding
protein complex binding
ion channel
transporter
potassium ion transport
regulation of ion transmembrane transport
sodium ion transmembrane transport
regulation of membrane potential
apical protein localization
retinal cone cell development
regulation of postsynaptic membrane potential
cellular response to cAMP
potassium ion transmembrane transport
regulation of membrane depolarization
transport
ion transport
sodium ion transport
negative regulation of action potential
response to calcium ion
transmembrane transport
regulation of membrane hyperpolarization
positive regulation of cation channel activity
inflammatory response
aging
cellular response to interferon-beta
maternal behavior
response to cisplatin
response to L-glutamate
