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产品信息
PA5-103269
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ICK(Accession Q9UPZ9), corresponding to amino acid residues around phosphorylated Tyr159.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2815968
产品详细信息
Antibody detects endogenous levels of ICK only when phosphorylated at Tyr159.
靶标信息
ICK or intestinal cell kinase belongs to a very extensive family of proteins that share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. ICK encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. ICK localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. ICK purified from transfected human embryonic kidney cells undergoes autophosphorylation and phosphorylates a test protein. ICK plays a key role in development of central nervous, skeletal, and endocrine systems.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ciliogenesis associated kinase 1; heart serine-threonine protein kinase; hICK; Intestinal cell kinase; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; mICK; MRK; serine/threonine protein kinase; Serine/threonine-protein kinase ICK
基因别名: 2210420N10Rik; AI848300; CILK1; ECO; ICK; KIAA0936; LCK2; MRK
UniProt ID: (Human) Q9UPZ9, (Rat) Q62726, (Mouse) Q9JKV2
Entrez Gene ID: (Human) 22858, (Rat) 84411, (Mouse) 56542
magnesium ion binding
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
metal ion binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
