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Phospho-IKK gamma (Ser376) Antibody (PA5-118521) in ICC/IF
Immunocytochemical analysis of Phospho-IKK gamma (Ser376) in Heat-shock treated Hela cells using a Phospho-IKK gamma (Ser376) polyclonal antibody (Product # PA5-118521). The samples were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. Samples were then incubated with the primary antibody and mouse anti-beta tubulin Ab for 1 hour at 37°C. An AlexaFluor5... View More
产品信息
PA5-118521
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human IKBKG(Accession Q9Y6K9), corresponding to amino acid residues around phosphorylated Ser376.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
sequential chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903023
产品详细信息
Antibody detects endogenous levels of IKK gamma only when phosphorylated at Ser376.
靶标信息
IKK gamma is the regulatory subunit of the inhibitor of the kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FIP-3; gikk; I-kappa-B kinase subunit gamma; ikB kinase subunit gamma; IkB kinase-associated protein 1; IKK-gamma; IKK3; IKKAP1; IKKG; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; mF; mFIP-3; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; OTTHUMP00000207079; OTTHUMP00000212188
基因别名: 1110037D23Rik; AI848108; AI851264; AMCBX1; AW124339; FIP-3; FIP3; Fip3p; IKBKG; IKK-gamma; IKK[g]; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
UniProt ID: (Human) Q9Y6K9, (Mouse) O88522
Entrez Gene ID: (Human) 8517, (Mouse) 16151
signal transducer activity
protein binding
protein domain specific binding
ubiquitin protein ligase binding
protein homodimerization activity
peroxisome proliferator activated receptor binding
metal ion binding
protein heterodimerization activity
K63-linked polyubiquitin binding
linear polyubiquitin binding
B cell homeostasis
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
activation of NF-kappaB-inducing kinase activity
positive regulation of gene expression
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
positive regulation of NF-kappaB transcription factor activity
establishment of vesicle localization
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
activation of MAPK activity
stimulatory C-type lectin receptor signaling pathway
apoptotic process
inflammatory response
immune response
I-kappaB kinase/NF-kappaB signaling
JNK cascade
response to virus
regulation of tumor necrosis factor-mediated signaling pathway
TRIF-dependent toll-like receptor signaling pathway
Fc-epsilon receptor signaling pathway
innate immune response
T cell receptor signaling pathway
stress-activated MAPK cascade
nucleotide-binding oligomerization domain containing signaling pathway
negative regulation of neuron death
