Invitrogen

Phospho-IP3 Receptor 1 (Tyr353) Polyclonal Antibody

Phospho-IP3 Receptor 1 (Tyr353) Antibody in Western Blot (WB)

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Phospho-IP3 Receptor 1 (Tyr353) Antibody (PA5-64735) in WB

EBioMedicine 2020 - Fig. 8 CD36 coordinates with Fyn to phosphorylate IP3R1, inducing lysosomal Ca 2+ overload and inflammation in preadipocytes. We constructed a lentivirus containing CD36 with a palmitoylation site mutation and infected the 3T3L1 cells with lentivirus (mtCD36 OE preadipocytes). (a) Co-IP for CD36 and Fyn in wtCD36 OE preadipocytes and mtCD36 OE preadipocytes ( n= 3). (b) Western blot analysis of IP3R1 and P-... View More

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产品信息

PA5-64735

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human IP3 Receptor (Phospho-Tyr353)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2662549

产品详细信息

Phospho-IP3 Receptor 1 (Tyr353) Polyclonal Antibody detects endogenous levels of IP3 Receptor 1 only when phosphorylated at Tyr353.

靶标信息

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.

EBioMedicine

Luo X,Li Y,Yang P,Chen Y,Wei L,Yu T,Xia J,Ruan XZ,Zhao L,Chen Y

PA5-64735 was used in Western Blotting to investigate whether preadipocyte CD36 is involved in adipose tissue inflammation and whether CD36 regulates lysosomal function.

Mon Jun 01 00:00:00 EDT 2020

Obesity induces preadipocyte CD36 expression promoting inflammation via the disruption of lysosomal calcium homeostasis and lysosome function.

EBioMedicine

Luo X,Li Y,Yang P,Chen Y,Wei L,Yu T,Xia J,Ruan XZ,Zhao L,Chen Y

PA5-64735 was used in Western Blotting to investigate whether preadipocyte CD36 is involved in adipose tissue inflammation and whether CD36 regulates lysosomal function.

Mon Jun 01 00:00:00 EDT 2020

生物信息学

蛋白别名: Inositol 1,4,5 trisphosphate receptor; inositol 1,4,5-triphosphate receptor 1; inositol 1,4,5-triphosphate receptor, type 1; Inositol 1,4,5-trisphosphate receptor; Inositol 1,4,5-trisphosphate receptor type 1; inositol 1,4,5-trisphosphate receptor, type 1; Inositol 1,4,5-trisphosphate-binding protein P400; Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1; InsP3R type I; insP3R1; InsP>3

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基因别名: ACV; CLA4; D6Pas2; ENSMUSG00000072853; Gm10429; I145TR; InsP3R; INSP3R1; IP3R; IP3R1; Itpr-1; ITPR1; opt; P400; Pcd6; Pcp-1; Pcp1; PPP1R94; SCA15; SCA16; SCA29

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UniProt ID: (Human) Q14643, (Mouse) P11881, (Rat) P29994

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Entrez Gene ID: (Human) 3708, (Mouse) 16438, (Rat) 25262

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功能