Invitrogen

Phospho-LRRK2 (Ser935) Recombinant Rabbit Monoclonal Antibody (3H8L19)

查看其他23个LRRK2抗体
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说明书
实验方案
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产品信息

701066

应用
建议稀释比
已发表文章

免疫印迹 (WB)

2-5 µg/mL
-

免疫组化（石蜡） (IHC (P))

1:10-1:50
-

免疫细胞化学 (ICC/IF)

1 µg/mL
- -
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Monoclonal

类型

Antibody

克隆号

3H8L19

抗原

Phosphopeptide corresponding to amino acids 930-940 of human LRRK2
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2532367

产品详细信息

This antibody is predicted to react with non-human primate, mouse and rat based on sequence homology.

Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

靶标信息

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: augmented in rheumatoid arthritis 17; BC 300-268; Dardarin; DKFZp434H2111; FLJ45829; leucine-rich repeat kinase 2; Leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; LRRK-2

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基因别名: AURA17; DARDARIN; LRRK2; PARK8; RIPK7; ROCO2

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UniProt ID: (Human) Q5S007

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Entrez Gene ID: (Human) 120892

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功能
SNARE binding glycoprotein binding actin binding GTPase activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity GTPase activator activity protein binding ATP binding GTP binding microtubule binding tubulin binding kinase activity Rho GTPase binding syntaxin-1 binding receptor signaling complex scaffold activity clathrin binding GTP-dependent protein kinase activity peroxidase inhibitor activity co-receptor binding identical protein binding protein homodimerization activity ion channel binding protein kinase A binding beta-catenin destruction complex binding scaffold/adaptor protein
参与通路
MAPK cascade activation of MAPKK activity activation of MAPK activity negative regulation of protein phosphorylation positive regulation of protein phosphorylation protein phosphorylation endocytosis autophagy response to oxidative stress mitochondrion organization Golgi organization lysosome organization small GTPase mediated signal transduction neuromuscular junction development determination of adult lifespan cellular response to starvation regulation of autophagy positive regulation of autophagy regulation of protein kinase A signaling negative regulation of protein processing regulation of neuron maturation negative regulation of macroautophagy phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation calcium-mediated signaling olfactory bulb development tangential migration from the subventricular zone to the olfactory bulb positive regulation of protein ubiquitination negative regulation of protein binding positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of GTPase activity cellular response to oxidative stress cellular protein localization intracellular signal transduction regulation of kidney size exploration behavior locomotory exploration behavior regulation of lysosomal lumen pH regulation of locomotion regulation of membrane potential positive regulation of programmed cell death positive regulation of MAP kinase activity positive regulation of GTPase activity GTP metabolic process protein autophosphorylation intracellular distribution of mitochondria neuron projection morphogenesis regulation of calcium-mediated signaling mitochondrion localization regulation of mitochondrial depolarization regulation of synaptic transmission, glutamatergic canonical Wnt signaling pathway excitatory postsynaptic potential regulation of dopamine receptor signaling pathway positive regulation of dopamine receptor signaling pathway regulation of canonical Wnt signaling pathway regulation of dendritic spine morphogenesis protein localization to mitochondrion neuron death cellular response to manganese ion reactive oxygen species metabolic process regulation of mitochondrial fission positive regulation of canonical Wnt signaling pathway negative regulation of excitatory postsynaptic potential regulation of neuron death negative regulation of neuron death negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of protein autoubiquitination regulation of neuroblast proliferation regulation of synaptic vesicle transport negative regulation of late endosome to lysosome transport negative regulation of autophagosome assembly negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation negative regulation of hydrogen peroxide-induced cell death negative regulation of protein targeting to mitochondrion negative regulation of protein processing involved in protein targeting to mitochondrion cellular response to dopamine Wnt signalosome assembly regulation of retrograde transport, endosome to Golgi regulation of branching morphogenesis of a nerve regulation of synaptic vesicle exocytosis negative regulation of peroxidase activity
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