Invitrogen

Phospho-MARK Pan (Thr215) Polyclonal Antibody

Phospho-MARK Pan (Thr215) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Phospho-MARK Pan (Thr215) Antibody (PA5-105814) in IHC (P)

Immunohistochemistry analysis of paraffin-embedded Phospho-MARK Pan (Thr215) in human kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-MARK Pan (Thr215) polyclonal antibody (Product # PA5-105814) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.

Phospho-MARK Pan (Thr215) Antibody in Western Blot (WB)

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产品信息

PA5-105814

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:3,000

免疫组化（石蜡） (IHC (P))

1:50-1:200

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human MARK1(Accession Q9P0L2), corresponding to amino acid residues around phosphorylated Thr215.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

sequential chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2817213

产品详细信息

Antibody detects endogenous levels of MARK1/2/3/4 only when phosphorylated at Thr215.

靶标信息

MARK1 (MAP/microtubule affinity-regulating kinase 1) belongs to the MARK family of serine/threonine kinases. MARK family protein kinases phosphorylate microtubule-associated proteins and may play a role in cytoskeletal stability. MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. MARK3 was originally identified as a marker that was induced by treatment with DNA damaging agents, and loss of MARK3 was found with carcinogenesis in the pancreas. MARK4 contains an N terminal serine/threonine kinase domain, a central ubiquitin associated domain, and a C terminal KA1 associated kinase domain. RT PCR analysis detects upregulated expression of the gene for MARK4 in nearly all clinical hepatocellular carcinoma cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C-TAK1; Cdc25C-associated protein kinase 1; cTAK1; ELKL motif kinase 1; ELKL motif kinase 2; ELKL motif serine-threonine protein kinase 3; ELKL motif serine/threonine-protein kinase 3; EMK-1; EMK-2; EMK1; EMK2/MARK3 serine-threonine protein kinase; MAP/microtubule affinity-regulating kinase 1; MAP/microtubule affinity-regulating kinase 2; MAP/microtubule affinity-regulating kinase 3; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase 4L; MAP/microtubule affinity-regulating kinase like 1; MAP/microtubule affinity-regulating kinase-like 1; MARK1; mark1 {ECO:0000312|RGD:619882}; MARK2; mark2 {ECO:0000312|RGD:708483}; MARK4 serine/threonine protein kinase; MPK-10; Par-1a; Par-1b; Par-1c; PAR1 homolog; PAR1 homolog b; PAR1 homolog c; Protein kinase STK10; Ser/Thr protein kinase PAR-1; Ser/Thr protein kinase PAR-1B; serine/threonine kinase; serine/threonine protein kinase EMK; Serine/threonine-protein kinase MARK1; Serine/threonine-protein kinase MARK2; Serine/threonine-protein kinase p78; testicular tissue protein Li 117

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基因别名: 1600015G02Rik; 2410090P21Rik; A430080F22Rik; AW491150; B930025N23Rik; C-TAK1; C79806; CTAK1; Emk; EMK-1; EMK1; EMK2; Emk3; ETK-1; ETK1; KIAA1477; KIAA1860; KP78; MARK; MARK1; MARK2; MARK3; MARK4; MARK4L; MARK4S; MARKL1; MARKL1L; mKIAA1477; mPar-1c; MPK10; PAR-1; Par-1a; Par-1b; Par-1c; PAR-1D; PAR1A; Par1b; Par1c