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Phospho-PP2A alpha/beta (Tyr307) Antibody (PA5-110150) in WB
Western blot analysis of Phospho-PP2A alpha/beta (Tyr307) in extracts of various cells. Samples were incubated with Phospho-PP2A alpha/beta (Tyr307) Polyclonal antibody (Product # PA5-110150) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. HeLa cells were treated by Calyculin A (100 nM) for 30 minutes after serum-starvation overnight. NIH... View More
产品信息
PA5-110150
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphorylated peptide around Y307 of human PPP2CA/PPP2CBPPP2CB (NP_0010095521)
偶联物
Unconjugated
形式
Liquid
浓度
1.69 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2855561
产品详细信息
Immunogen sequence: PDYFL
靶标信息
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: PP2A-alpha; PP2A-beta; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2, catalytic subunit, beta isoform; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2A catalytic subunit, beta isoform; protein phosphatase 2a, catalytic subunit, alpha isoform; protein phosphatase 2a, catalytic subunit, beta isoform; protein phosphatase type 2A catalytic subunit; Replication protein C; RP C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; testicular tissue protein Li 146
基因别名: AI115466; D8Ertd766e; PP2A; PP2Abeta; PP2Ac; PP2CA; PP2Calpha; PP2CB; PPP2CA; PPP2CB; R75353; RP-C
UniProt ID: (Human) P67775, (Human) P62714, (Mouse) P63330, (Mouse) P62715
Entrez Gene ID: (Human) 5515, (Human) 5516, (Mouse) 19052, (Mouse) 19053
phosphoprotein phosphatase activity
protein binding
protein C-terminus binding
metal ion binding
GABA receptor binding
protein serine/threonine phosphatase activity
hydrolase activity
enzyme binding
protein kinase binding
protein phosphatase binding
protein domain specific binding
protein complex binding
protein kinase B binding
ion channel binding
protein dimerization activity
tau protein binding
protein phosphatase 2A binding
protein antigen binding
protein phosphatase
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
inactivation of MAPK activity
regulation of DNA replication
regulation of transcription, DNA-templated
protein dephosphorylation
ceramide metabolic process
apoptotic process
mitotic nuclear envelope reassembly
mesoderm development
RNA splicing
response to organic substance
negative regulation of epithelial to mesenchymal transition
second-messenger-mediated signaling
regulation of Wnt signaling pathway
regulation of cell adhesion
negative regulation of cell growth
regulation of growth
negative regulation of tyrosine phosphorylation of Stat3 protein
regulation of cell differentiation
meiotic cell cycle
positive regulation of protein serine/threonine kinase activity
apoptotic mitochondrial changes
regulation of gene expression
response to endoplasmic reticulum stress
response to hydrogen peroxide
proteasome-mediated ubiquitin-dependent protein catabolic process
response to antibiotic
negative regulation of transcription from RNA polymerase II promoter
regulation of protein phosphorylation
negative regulation of protein phosphorylation
regulation of receptor activity
regulation of protein autophosphorylation
positive regulation of protein phosphatase type 2A activity
positive regulation of protein dephosphorylation
regulation of protein catabolic process
negative regulation of transcription factor import into nucleus
positive regulation of apoptotic process
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
regulation of cell cycle
protein heterotrimerization
cellular response to glucose stimulus
negative regulation of calcium ion transmembrane transporter activity
negative regulation of Ras protein signal transduction
